(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase

• Published in: Biological & pharmaceutical bulletin 2002, Vol.25(1), pp.125-127
• Main Authors: Sung, Sang Hyun, Kang, So Young, Lee, Ki Yong, Park, Mi Jung, Kim, Jeong Hun, Park, Jong Hee, Kim, Young Chul, Kim, Jinwoong, Kim, Young Choong
• Format: Article
• Language: English
• Subjects: (+)-α-viniferin; Acetylcholinesterase - chemistry; AChE inhibitors; Benzofurans - isolation & purification; Benzofurans - pharmacology; Biological and medical sciences; Butyrylcholinesterase - chemistry; Caragana chamlague; Cholinesterase Inhibitors - isolation & purification; Cholinesterase Inhibitors - pharmacology; Dose-Response Relationship, Drug; Fabaceae - chemistry; General pharmacology; Kinetics; kobophenol A; Leguminosae; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Roots - chemistry; Spectrophotometry, Infrared; Stilbenes - isolation & purification; Stilbenes - pharmacology
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.25.125

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-α-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 µM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.