Antibacterial and antiproliferative activity of cationic fullerene derivatives

We examined the antibacterial and antiproliferative activities of alkylated C(60)-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-12, Vol.13 (24), p.4395-4397
Main Authors: MASHINO, Tadahiko, NISHIKAWA, Dai, TAKAHASHI, Kyoko, USUI, Noriko, YAMORI, Takao, SEKI, Masako, ENDO, Toyoshige, MOCHIZUKI, Masataka
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic agents
Antineoplastic Agents - pharmacology
Bacteria - drug effects
Biological and medical sciences
Cell Division - drug effects
Cell Line, Tumor
Fullerenes - chemistry
Fullerenes - pharmacology
General aspects
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Summary:We examined the antibacterial and antiproliferative activities of alkylated C(60)-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.09.040