Host Responses to Cryptosporidium Infection

Cryptosporidium is a clinically and economically important infection whose pathogenic effect begins with colonization of the intestinal epithelium. Despite intensive efforts, a consistently effective therapy for the infection has yet to be identified. Morbidity and mortality results from ongoing los...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2002-01, Vol.16 (1), p.12-21
Main Authors: Gookin, Jody L., Nordone, Shila K., Argenzio, Robert A.
Format: Article
Language:English
Subjects:
Animals
Cattle - parasitology
Cattle Diseases - immunology
Cattle Diseases - parasitology
Cattle Diseases - physiopathology
Cryptosporidiosis
Cryptosporidiosis - parasitology
Cryptosporidiosis - veterinary
Cryptosporidium
Cryptosporidium - pathogenicity
Diarrhea
Diarrhea - physiopathology
Diarrhea - veterinary
Host-Parasite Interactions
Immunity
Immunity, Mucosal
Intestinal epithelium
Intestinal Mucosa - immunology
Intestinal Mucosa - physiology
Pathogenesis
Swine - parasitology
Swine Diseases - immunology
Swine Diseases - parasitology
Swine Diseases - physiopathology
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Summary:Cryptosporidium is a clinically and economically important infection whose pathogenic effect begins with colonization of the intestinal epithelium. Despite intensive efforts, a consistently effective therapy for the infection has yet to be identified. Morbidity and mortality results from ongoing loss of absorptive epithelium, which leads to villous atrophy and malabsorption and release of inflammatory mediators that stimulate electrolyte secretion and diarrhea. With further clarification of the mechanisms underlying enterocyte malfunction in Cryptosporidium infection, it should be possible to design rational nutritional and pharmacologic therapies to enhance nutrient and water absorption, promote the clearance of infected enterocytes, and restore normal villus architecture and mucosal barrier function.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2002.tb01602.x