Regulatory Strategies in the Complexation and Release of a Noncovalent Guest Trimer by a Self-Assembled Molecular Cage

Primitive similarities with regulatory strategies of natural systems have been mimicked by a synthetic self‐assembled receptor. The complexation of a hydrogen‐bonded trimer inside a hydrogen‐bonded molecular cage triggers similar large conformational changes to the ones occurring in enzymes upon com...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2003-12, Vol.42 (46), p.5717-5722
Main Authors: Kerckhoffs, Jessica M. C. A., van Leeuwen, Fijs W. B., Spek, Anthony L., Kooijman, Huub, Crego-Calama, Mercedes, Reinhoudt, David N.
Format: Article
Language:English
Subjects:
enzyme mimics
host-guest systems
hydrogen bonds
receptors
self-assembly
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Summary:Primitive similarities with regulatory strategies of natural systems have been mimicked by a synthetic self‐assembled receptor. The complexation of a hydrogen‐bonded trimer inside a hydrogen‐bonded molecular cage triggers similar large conformational changes to the ones occurring in enzymes upon complexation of a specific substrate. Controlled release is also achieved (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352733