Efficient Route to 1,3-Di-N-imidazolylbenzene. A Comparison of Monodentate vs Bidentate Carbenes in Pd-Catalyzed Cross Coupling

A new bis(carbene) ligand architecture has been developed and was evaluated in the Suzuki−Miyaura cross-coupling reaction of various aryl halides with phenylboronic acid. Several new bis(carbene) ligands were tested in different carbene:Pd ratios. Pd(OAc)2 and Pd2(dba)3 were compared for efficiency...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2003-12, Vol.5 (25), p.4847-4849
Main Authors: Vargas, Victor C, Rubio, Ramel J, Hollis, T. Keith, Salcido, Martha E
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new bis(carbene) ligand architecture has been developed and was evaluated in the Suzuki−Miyaura cross-coupling reaction of various aryl halides with phenylboronic acid. Several new bis(carbene) ligands were tested in different carbene:Pd ratios. Pd(OAc)2 and Pd2(dba)3 were compared for efficiency as a Pd source. It was found that the Pd(OAc)2/bis(carbene) system formed a catalyst for the activation of chlorobenzene.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035906z