Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro

Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan...

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Bibliographic Details
Published in:Biomaterials 2002-03, Vol.23 (6), p.1411-1416
Main Authors: Ahn, Jae-Soon, Choi, Hoo-Kyun, Chun, Myong-Kwan, Ryu, Jei-Man, Jung, Jae-Hee, Kim, Yue-Un, Cho, Chong-Su
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Adhesives
Biocompatible Materials - pharmacokinetics
Blood
Chitin - analogs & derivatives
Chitin - chemistry
Chitosan
Chromatography, High Pressure Liquid
Drug therapy
Hydrogen-Ion Concentration
Organic acids
pH effects
Plastic films
Plastics - chemistry
Poly(acrylic acid)
Polymerization
Polymers - chemistry
Spectroscopy, Fourier Transform Infrared
Template polymerization
Time Factors
Tissue Adhesions
Transmucosal drug delivery
Triamcinolone acetonide
Triamcinolone Acetonide - pharmacokinetics
X-Ray Diffraction
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Summary:Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan and poly(acrylic acid) (PAA) was prepared by template polymerization of acrylic acid in the presence of chitosan for the TMD system. Triamcinolone acetonide (TAA) was loaded into the chitosan/PAA polymer complex film. TAA was evenly dispersed in chitosan/PAA polymer complex film without interaction with polymer complex. Release behavior of TAA from the mucoadhesive polymer film was dependent on time, pH, loading content of drug, and chitosan/PAA ratio. The analysis of the drug release from the mucoadhesive film showed that TAA might be released from the chitosan/PAA polymer complex film through non-Fickian diffusion mechanism.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00261-7