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Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro
Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan...
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| Published in: | Biomaterials 2002-03, Vol.23 (6), p.1411-1416 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c423t-3e74093d8d40b90058dc8223c9f113773a31c8707c988d20eeaa1d999f91803 |
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| cites | cdi_FETCH-LOGICAL-c423t-3e74093d8d40b90058dc8223c9f113773a31c8707c988d20eeaa1d999f91803 |
| container_end_page | 1416 |
| container_issue | 6 |
| container_start_page | 1411 |
| container_title | Biomaterials |
| container_volume | 23 |
| creator | Ahn, Jae-Soon Choi, Hoo-Kyun Chun, Myong-Kwan Ryu, Jei-Man Jung, Jae-Hee Kim, Yue-Un Cho, Chong-Su |
| description | Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan and poly(acrylic acid) (PAA) was prepared by template polymerization of acrylic acid in the presence of chitosan for the TMD system. Triamcinolone acetonide (TAA) was loaded into the chitosan/PAA polymer complex film. TAA was evenly dispersed in chitosan/PAA polymer complex film without interaction with polymer complex. Release behavior of TAA from the mucoadhesive polymer film was dependent on time, pH, loading content of drug, and chitosan/PAA ratio. The analysis of the drug release from the mucoadhesive film showed that TAA might be released from the chitosan/PAA polymer complex film through non-Fickian diffusion mechanism. |
| doi_str_mv | 10.1016/S0142-9612(01)00261-7 |
| format | article |
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A novel mucoadhesive polymer complex composed of chitosan and poly(acrylic acid) (PAA) was prepared by template polymerization of acrylic acid in the presence of chitosan for the TMD system. Triamcinolone acetonide (TAA) was loaded into the chitosan/PAA polymer complex film. TAA was evenly dispersed in chitosan/PAA polymer complex film without interaction with polymer complex. Release behavior of TAA from the mucoadhesive polymer film was dependent on time, pH, loading content of drug, and chitosan/PAA ratio. The analysis of the drug release from the mucoadhesive film showed that TAA might be released from the chitosan/PAA polymer complex film through non-Fickian diffusion mechanism.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(01)00261-7</identifier><identifier>PMID: 11829436</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Acrylic Resins - chemistry ; Adhesives ; Biocompatible Materials - pharmacokinetics ; Blood ; Chitin - analogs & derivatives ; Chitin - chemistry ; Chitosan ; Chromatography, High Pressure Liquid ; Drug therapy ; Hydrogen-Ion Concentration ; Organic acids ; pH effects ; Plastic films ; Plastics - chemistry ; Poly(acrylic acid) ; Polymerization ; Polymers - chemistry ; Spectroscopy, Fourier Transform Infrared ; Template polymerization ; Time Factors ; Tissue Adhesions ; Transmucosal drug delivery ; Triamcinolone acetonide ; Triamcinolone Acetonide - pharmacokinetics ; X-Ray Diffraction</subject><ispartof>Biomaterials, 2002-03, Vol.23 (6), p.1411-1416</ispartof><rights>2002 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-3e74093d8d40b90058dc8223c9f113773a31c8707c988d20eeaa1d999f91803</citedby><cites>FETCH-LOGICAL-c423t-3e74093d8d40b90058dc8223c9f113773a31c8707c988d20eeaa1d999f91803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11829436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Jae-Soon</creatorcontrib><creatorcontrib>Choi, Hoo-Kyun</creatorcontrib><creatorcontrib>Chun, Myong-Kwan</creatorcontrib><creatorcontrib>Ryu, Jei-Man</creatorcontrib><creatorcontrib>Jung, Jae-Hee</creatorcontrib><creatorcontrib>Kim, Yue-Un</creatorcontrib><creatorcontrib>Cho, Chong-Su</creatorcontrib><title>Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan and poly(acrylic acid) (PAA) was prepared by template polymerization of acrylic acid in the presence of chitosan for the TMD system. Triamcinolone acetonide (TAA) was loaded into the chitosan/PAA polymer complex film. TAA was evenly dispersed in chitosan/PAA polymer complex film without interaction with polymer complex. Release behavior of TAA from the mucoadhesive polymer film was dependent on time, pH, loading content of drug, and chitosan/PAA ratio. The analysis of the drug release from the mucoadhesive film showed that TAA might be released from the chitosan/PAA polymer complex film through non-Fickian diffusion mechanism.</description><subject>Acrylic Resins - chemistry</subject><subject>Adhesives</subject><subject>Biocompatible Materials - pharmacokinetics</subject><subject>Blood</subject><subject>Chitin - analogs & derivatives</subject><subject>Chitin - chemistry</subject><subject>Chitosan</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug therapy</subject><subject>Hydrogen-Ion Concentration</subject><subject>Organic acids</subject><subject>pH effects</subject><subject>Plastic films</subject><subject>Plastics - chemistry</subject><subject>Poly(acrylic acid)</subject><subject>Polymerization</subject><subject>Polymers - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Template polymerization</subject><subject>Time Factors</subject><subject>Tissue Adhesions</subject><subject>Transmucosal drug delivery</subject><subject>Triamcinolone acetonide</subject><subject>Triamcinolone Acetonide - pharmacokinetics</subject><subject>X-Ray Diffraction</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkU2LFDEQhoMo7uzqT1Bykt1Da1WS7iQnkUVXYUFwvYdsUs1GujuzSc_A_Ht7PtDjnIqC530L6mHsHcJHBOw-PQAq0dgOxTXgDYDosNEv2AqNNk1roX3JVv-QC3ZZ6x9YdlDiNbtANMIq2a3Y8y8ayFfiuedzSX4MacpDnoj7QHOeUiTelzzycROyj09U05b4Og-7kQoPeVznSnGfDk9pztVP3E_xAFz7UHZDCktTijc8TXyb5pLfsFe9Hyq9Pc0r9vDt6-_b7839z7sft1_um6CEnBtJWoGV0UQFjxagNTEYIWSwPaLUWnqJwWjQwRoTBRB5j9Fa21s0IK_Yh2PruuTnDdXZjakGGgY_Ud5Up1FJVEacBYXuTGuVPQ-iaq3APdgewVByrYV6ty5p9GXnENzenTu4c3sxDtAd3Dm95N6fDmweR4r_UydZC_D5CNDytm2i4mpINAWKqVCYXczpzIm_Z3ypCA</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Ahn, Jae-Soon</creator><creator>Choi, Hoo-Kyun</creator><creator>Chun, Myong-Kwan</creator><creator>Ryu, Jei-Man</creator><creator>Jung, Jae-Hee</creator><creator>Kim, Yue-Un</creator><creator>Cho, Chong-Su</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro</title><author>Ahn, Jae-Soon ; Choi, Hoo-Kyun ; Chun, Myong-Kwan ; Ryu, Jei-Man ; Jung, Jae-Hee ; Kim, Yue-Un ; Cho, Chong-Su</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-3e74093d8d40b90058dc8223c9f113773a31c8707c988d20eeaa1d999f91803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Adhesives</topic><topic>Biocompatible Materials - pharmacokinetics</topic><topic>Blood</topic><topic>Chitin - analogs & derivatives</topic><topic>Chitin - chemistry</topic><topic>Chitosan</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug therapy</topic><topic>Hydrogen-Ion Concentration</topic><topic>Organic acids</topic><topic>pH effects</topic><topic>Plastic films</topic><topic>Plastics - chemistry</topic><topic>Poly(acrylic acid)</topic><topic>Polymerization</topic><topic>Polymers - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Template polymerization</topic><topic>Time Factors</topic><topic>Tissue Adhesions</topic><topic>Transmucosal drug delivery</topic><topic>Triamcinolone acetonide</topic><topic>Triamcinolone Acetonide - pharmacokinetics</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Jae-Soon</creatorcontrib><creatorcontrib>Choi, Hoo-Kyun</creatorcontrib><creatorcontrib>Chun, Myong-Kwan</creatorcontrib><creatorcontrib>Ryu, Jei-Man</creatorcontrib><creatorcontrib>Jung, Jae-Hee</creatorcontrib><creatorcontrib>Kim, Yue-Un</creatorcontrib><creatorcontrib>Cho, Chong-Su</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Jae-Soon</au><au>Choi, Hoo-Kyun</au><au>Chun, Myong-Kwan</au><au>Ryu, Jei-Man</au><au>Jung, Jae-Hee</au><au>Kim, Yue-Un</au><au>Cho, Chong-Su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>23</volume><issue>6</issue><spage>1411</spage><epage>1416</epage><pages>1411-1416</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Transmucosal drug delivery (TMD) system using mucoadhesive polymer has been recently interested due to the rapid onset of action, high blood level, avoidance of the first-pass effect and the exposure of the drug to the gastrointestinal tract. A novel mucoadhesive polymer complex composed of chitosan and poly(acrylic acid) (PAA) was prepared by template polymerization of acrylic acid in the presence of chitosan for the TMD system. Triamcinolone acetonide (TAA) was loaded into the chitosan/PAA polymer complex film. TAA was evenly dispersed in chitosan/PAA polymer complex film without interaction with polymer complex. Release behavior of TAA from the mucoadhesive polymer film was dependent on time, pH, loading content of drug, and chitosan/PAA ratio. The analysis of the drug release from the mucoadhesive film showed that TAA might be released from the chitosan/PAA polymer complex film through non-Fickian diffusion mechanism.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11829436</pmid><doi>10.1016/S0142-9612(01)00261-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2002-03, Vol.23 (6), p.1411-1416 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Acrylic Resins - chemistry Adhesives Biocompatible Materials - pharmacokinetics Blood Chitin - analogs & derivatives Chitin - chemistry Chitosan Chromatography, High Pressure Liquid Drug therapy Hydrogen-Ion Concentration Organic acids pH effects Plastic films Plastics - chemistry Poly(acrylic acid) Polymerization Polymers - chemistry Spectroscopy, Fourier Transform Infrared Template polymerization Time Factors Tissue Adhesions Transmucosal drug delivery Triamcinolone acetonide Triamcinolone Acetonide - pharmacokinetics X-Ray Diffraction |
| title | Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro |
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