Characteristics of distribution of nitric oxide synthase containing neurons in the medullary cardiovascular centers of dogs and rats

The aim of the study was to characterize species-related differences in the distribution of nitric oxide synthase (NOS)-containing neurons in the medullary structures of dogs and rats involved in the regulation of the sympathetic or parasympathetic drives. Two main results have been obtained, namely...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2003, Vol.49 (5), p.13-24
Main Authors: Datsenko, V V, Pavliuchenko, V B, Moĭbenko, O O, Piliavs'kyĭ, O I, Kostiukov, O I, Maĭs'kyĭ, V O
Format: Article
Language:Ukrainian
Subjects:
Afferent Pathways
Animals
Cardiovascular Physiological Phenomena
Cardiovascular System - innervation
Dogs
Ganglia, Sympathetic - cytology
Ganglia, Sympathetic - enzymology
Ganglia, Sympathetic - physiology
Male
Medulla Oblongata - cytology
Medulla Oblongata - enzymology
Medulla Oblongata - physiology
Neurons, Afferent - enzymology
Neurons, Afferent - physiology
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase - biosynthesis
Rats
Rats, Wistar
Solitary Nucleus - cytology
Solitary Nucleus - enzymology
Solitary Nucleus - physiology
Species Specificity
Tissue Distribution
Vagus Nerve - cytology
Vagus Nerve - enzymology
Vagus Nerve - physiology
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Summary:The aim of the study was to characterize species-related differences in the distribution of nitric oxide synthase (NOS)-containing neurons in the medullary structures of dogs and rats involved in the regulation of the sympathetic or parasympathetic drives. Two main results have been obtained, namely: (i) the average number of NOS-containing neurons in the dorsomedial and ventrolateral medulla per section in dog was larger than that in rat, while the density of the positive cells in the both regions in dog was less than that in rat. (ii) Within the dorsal motor nucleus of vagus a lot of NOS-containing cells (preganglionic vagal neurons) were observed only in dog. Differences in the distribution of NO-generating neurons in the medullary cardiovascular centers, and heterogeneity in the basal level of NO release may contribute to the peculiarities of the hemodynamic responses induced by NOS inhibitors in these species.
ISSN:2522-9028