Non-enzymatic covalent modifications of proteins: mechanisms, physiological consequences and clinical applications

Given the complexity of the biosynthetic machinery and the delicate chemical composition of proteins, it is remarkable that cells manage to produce and maintain normally functioning proteins under most conditions. However, it is now well known that proteins are susceptible to various non-enzymatic c...

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Bibliographic Details
Published in:Matrix Biology 2002, Vol.21 (1), p.39-52
Main Authors: Cloos, Paul A.C, Christgau, Stephan
Format: Article
Language:English
Subjects:
Animals
Conformational damage
Covalent damage
Cross-linking
Cross-Linking Reagents
Glycation
Glycation End Products, Advanced - chemistry
Glycation End Products, Advanced - physiology
Humans
Isomerism
Isomerization
Oxidation
Oxidation-Reduction
Protein Conformation
Proteins - chemistry
Proteins - physiology
Racemization
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Summary:Given the complexity of the biosynthetic machinery and the delicate chemical composition of proteins, it is remarkable that cells manage to produce and maintain normally functioning proteins under most conditions. However, it is now well known that proteins are susceptible to various non-enzymatic covalent modifications (NECM) under physiological conditions. Such modifications can be of no or little importance to the protein or they can be absolutely detrimental. Often NECM are difficult to study due to the complex and technically demanding methods required to identify many of these modifications. Thus, the role of NECM has not yet been adequately resolved but recent research has allowed a better understanding of such modifications. The present review outlines the various forms of NECM that involve covalent modifications of proteins, and discusses their relevance, biological impact and potential applications in the study of protein turnover and diagnosis of disease.
ISSN:0945-053X
1569-1802
DOI:10.1016/S0945-053X(01)00188-3