Myelin proteolipid protein—the first 50 years

Myelin proteolipid protein (PLP), the most abundant protein of central nervous system (CNS) myelin, is a hydrophobic integral membrane protein. Because of its physical properties, which make it difficult to work with, progress towards determining the exact function(s) and disease associations of mye...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2002-03, Vol.34 (3), p.211-215
Main Authors: Greer, Judith M, Lees, Marjorie B
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Humans
Molecular Sequence Data
Myelin
Myelin Proteolipid Protein - chemistry
Myelin Proteolipid Protein - genetics
Myelin Proteolipid Protein - metabolism
Nervous System Diseases - genetics
Nervous System Diseases - physiopathology
Neurological disease
Protein Structure, Secondary
Proteolipid protein
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Summary:Myelin proteolipid protein (PLP), the most abundant protein of central nervous system (CNS) myelin, is a hydrophobic integral membrane protein. Because of its physical properties, which make it difficult to work with, progress towards determining the exact function(s) and disease associations of myelin PLP has been slow. However, recent molecular biology advances have given new life to investigations of PLP, and suggest that it has multiple functions within myelin and is of importance in several neurological disorders.
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(01)00136-4