Platelet Adhesion to Simulated Stented Surfaces

Purpose: To determine if the protrusion of stent struts into the flow stream, which creates stagnation along the wall dependent on the strut spacing, has an effect on platelet adhesion. Methods: Three 2-dimensional stents with different strut spacings were placed in a flat-plate flow chamber. Human...

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Bibliographic Details
Published in:Journal of endovascular therapy 2003-10, Vol.10 (5), p.978-986
Main Authors: Robaina, Samuel, Jayachandran, Bhavani, He, Yong, Frank, Andreas, Moreno, Michael R., Schoephoerster, Richard T., Moore, James E.
Format: Article
Language:English
Subjects:
Blood Platelets - physiology
Cell Adhesion
Computer Simulation
Hemorheology
Humans
Stents
Surface Properties
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Summary:Purpose: To determine if the protrusion of stent struts into the flow stream, which creates stagnation along the wall dependent on the strut spacing, has an effect on platelet adhesion. Methods: Three 2-dimensional stents with different strut spacings were placed in a flat-plate flow chamber. Human blood was collected and platelets were labeled with indium 111. The blood with radioactive platelets was pumped through the flow chamber for 30 minutes to produce a pulsatile wall shear stress of 10±5 dynes/cm2 (mean ± amplitude at 1 Hz). A gamma counter measured radioactivity along the surface and on the stents. Computational flow simulations provided specific data on flow separation and wall shear stress for each stent strut spacing tested (2.5, 4.0, and 7.0 times the strut height). Results: The presence of any stent provoked an elevation in platelet adhesion within the stented region (p
ISSN:1526-6028
1545-1550
DOI:10.1177/152660280301000522