New Method of Synthesis of Vinca Alkaloid Derivatives

Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the stan...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (3), p.505-507
Main Authors: Fahy, Jacques, Thillaye du Boullay, Valérie, Bigg, Dennis C.H
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemical synthesis
Biological and medical sciences
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
General aspects
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Tubulin Modulators
Vinca Alkaloids - chemical synthesis
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Summary:Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids. Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds 10– 11 have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00784-3