Nevirapine to prevent mother-to-child transmission of HIV-1 among women of unknown serostatus

The Lusaka District programme is among the largest and most successful nevirapine-based MTCT-prevention services in the world;10 nearly 3000 pregnant women are tested for HIV-1 infection each month. However, the history of the programme's implementation shows how offering nevirapine to women of...

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Bibliographic Details
Published in:The Lancet (British edition) 2003-11, Vol.362 (9398), p.1850-1853
Main Authors: Stringer, Jeffrey SA, Rouse, Dwight J, Sinkala, Moses, Marseille, Elliot A, Vermund, Sten H, Stringer, Elizabeth M, Goldenberg, Robert L
Format: Article
Language:English
Subjects:
Africa
AIDS Serodiagnosis - statistics & numerical data
Anti-HIV Agents - therapeutic use
Biological and medical sciences
Female
HIV
HIV Infections - diagnosis
HIV Infections - prevention & control
HIV Infections - transmission
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious Disease Transmission, Vertical - prevention & control
Infectious Disease Transmission, Vertical - statistics & numerical data
Infectious diseases
Medical sciences
Medical treatment
Nevirapine - therapeutic use
Pregnancy
Prevention
Preventive Health Services - supply & distribution
Prophylaxis
Training
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:The Lusaka District programme is among the largest and most successful nevirapine-based MTCT-prevention services in the world;10 nearly 3000 pregnant women are tested for HIV-1 infection each month. However, the history of the programme's implementation shows how offering nevirapine to women of unknown HIV-1-status could greatly improve population coverage of the drug. The programme began in two clinics with intensive training in all practical aspects of MTCT prevention. The majority of time was spent on VCT training of midwives and other health-care workers. During the 19 months that it took to fully deploy MTCT-prevention services in Lusaka, more than 7000 HIV-1-infected women gave birth in clinics that did not yet have VCT services; thus, more than 7000 infants were exposed to HIV-1 but received no prophylaxis, despite the district pharmacy being fully stocked with nevirapine.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(03)14907-0