Furoquinoline alkaloids from Teclea nobilis

Five new furoquinoline alkaloids, namely tecleabine ( 1), tecleoxine ( 2), isotecleoxine ( 3), methylnkolbisine ( 4) and chlorodesnkolbisine ( 5) were isolated from the aerial parts of Teclea nobilis, together with seven known furoquinoline derivatives; one acridone alkaloid, and one known flavanone...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2003-12, Vol.64 (8), p.1405-1411
Main Authors: Al-Rehaily, Adnan J., Ahmad, Mohammad S., Muhammad, Ilias, Al-Thukair, Assad A., Perzanowski, Herman P.
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
antibacterial properties
antifungal properties
Biological and medical sciences
Candida albicans
Chemical constitution
chemical structure
Chlorodesnkolbisine
Cryptococcus neoformans
Fluoroquinolones - chemistry
Fluoroquinolones - isolation & purification
Fundamental and applied biological sciences. Psychology
Furoquinoline
furoquinoline alkaloids
Isotecleoxine
Methylnkolbisine
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
phytochemicals
Plant Components, Aerial - chemistry
plant extracts
Plant physiology and development
Plasmodium falciparum
Quinolines - chemistry
Rutaceae
Rutaceae - chemistry
spectral analysis
Spectrometry, Mass, Electrospray Ionization - methods
Staphylococcus aureus
Teclea
Teclea nobilis
Tecleabine
Tecleoxine
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Summary:Five new furoquinoline alkaloids, namely tecleabine ( 1), tecleoxine ( 2), isotecleoxine ( 3), methylnkolbisine ( 4) and chlorodesnkolbisine ( 5) were isolated from the aerial parts of Teclea nobilis, together with seven known furoquinoline derivatives; one acridone alkaloid, and one known flavanone. The structures of the alkaloids 1– 5 were established by 1D and 2D NMR spectral data, including COSY, HMQC and HMBC experiments, as well as HRMS. Five new furoquinoline alkaloids ( 1– 5), along with seven known furoquinolines, one acridone alkaloid and one known flavanone were isolated from Teclea nobilis Delile. Their structures were established by spectral analysis, including 2D NMR data.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2003.09.013