Genetic variability of hepatitis A virus

1 Department of Biochemistry, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6 2 Laboratoire de Virologie Moléculaire et Structurale, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France 3 Laboratorie de Virologie UPRES-EA1156, Institut de Biologie, Centre Hospit...

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Published in:Journal of general virology 2003-12, Vol.84 (12), p.3191-3201
Main Authors: Costa-Mattioli, Mauro, Napoli, Anna Di, Ferre, Virginie, Billaudel, Sylviane, Perez-Bercoff, Raul, Cristina, Juan
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigenic Variation
Biological Evolution
Canada - epidemiology
Europe - epidemiology
Genetic Variation
Genotype
Hepatitis A - epidemiology
Hepatitis A Antigens - genetics
Hepatitis A virus
Hepatitis A Virus, Human - classification
Hepatitis A Virus, Human - genetics
Humans
Incidence
Molecular Epidemiology
Molecular Sequence Data
Mutation
Recombination, Genetic
RNA, Viral - genetics
Sequence Alignment
South America - epidemiology
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Summary:1 Department of Biochemistry, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6 2 Laboratoire de Virologie Moléculaire et Structurale, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France 3 Laboratorie de Virologie UPRES-EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, Rue Quai Moncousu 9, 44093 Nantes, France 4 Departamento de Técnicas Nucleares Aplicadas, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Igua 4225, 11400 Montevideo, Uruguay Correspondence Mauro Costa-Mattioli mauro.costa-mattioli{at}mail.mcgill.ca Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic variability and molecular epidemiology of HAV. Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed. Published ahead of print on 25 September 2003 as DOI 10.1099/vir.0.19532-0.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.19532-0