Neuronal Migration, Cerebral Cortical Development, and Cerebral Cortical Anomalies

Cerebral cortical malformations are relatively common anomalies identified by neuroimaging and pathologically in patients with epilepsy and mental retardation. A disruption in neuronal migration during central nervous system development has been postulated as the pathogenesis for many of these disor...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2002-01, Vol.61 (1), p.1-11
Main Authors: PILZ, DANIELA, STOODLEY, NEIL, GOLDEN, JEFFREY A
Format: Article
Language:English
Subjects:
1-Alkyl-2-acetylglycerophosphocholine Esterase
Animals
Biological and medical sciences
Cell Movement
Cerebral Cortex - abnormalities
Cerebral Cortex - anatomy & histology
Cerebral Cortex - embryology
Cerebral Cortex - growth & development
Cerebral Cortex - physiology
Humans
Magnetic Resonance Imaging
Malformations of the nervous system
Medical sciences
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Models, Neurological
Neurology
Neurons - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cerebral cortical malformations are relatively common anomalies identified by neuroimaging and pathologically in patients with epilepsy and mental retardation. A disruption in neuronal migration during central nervous system development has been postulated as the pathogenesis for many of these disorders. Recently, the cell migration hypothesis has been proven accurate for lissencephaly, subcortical band heterotopia, and periventricular nodular heterotopia. Furthermore, advances in cellular and molecular biology have begun elucidating the fundamental mechanisms underlying these migration disorders. These data have resulted in redefining and recategorizing specific malformations based on their molecular genetic abnormality. In this review we shall discuss the current understanding of neuronal migration in the developing cerebral cortex, the evaluation of these patients, and attempt to describe the pathogenesis for several well-characterized human disorders of cell migration.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/61.1.1