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Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates
Background: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity. Methods: We evaluated 10 infants born by vaginal delivery...
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| Published in: | Pediatric anesthesia 2002-01, Vol.12 (1), p.59-64 |
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| container_title | Pediatric anesthesia |
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| creator | GASPARONI, A CIARDELLI, L DE AMICI, D CASTELLAZZI, A. M AUTELLI, M BOTTINO, R POLITO, E BARTOLI, A RONDINI, G CHIRICO, G |
| description | Background: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity.
Methods: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C).
Results: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10.
Conclusions: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine‐immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia. |
| doi_str_mv | 10.1046/j.1460-9592.2002.00752.x |
| format | article |
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Methods: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C).
Results: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10.
Conclusions: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine‐immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia.</description><identifier>ISSN: 1155-5645</identifier><identifier>EISSN: 1460-9592</identifier><identifier>DOI: 10.1046/j.1460-9592.2002.00752.x</identifier><identifier>PMID: 11849577</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Anesthesia, Epidural ; Anesthesia, General ; Anesthesia, Obstetrical ; Anesthetics, Inhalation ; Anesthetics, Local ; Cesarean Section ; Delivery, Obstetric ; Humans ; Infant, Newborn - immunology ; Infant, Newborn - metabolism ; Killer Cells, Natural - immunology ; Lidocaine ; Methyl Ethers ; mode of delivery ; neutrophil function ; Neutrophils - immunology ; NK activity ; Respiratory Burst ; sevoflurane ; thyroid hormones ; Thyroid Hormones - metabolism</subject><ispartof>Pediatric anesthesia, 2002-01, Vol.12 (1), p.59-64</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4022-8febf0978df541c1a4a2573c441008209d3fc5715177a28511673a3c41f94f2c3</citedby><cites>FETCH-LOGICAL-c4022-8febf0978df541c1a4a2573c441008209d3fc5715177a28511673a3c41f94f2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11849577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GASPARONI, A</creatorcontrib><creatorcontrib>CIARDELLI, L</creatorcontrib><creatorcontrib>DE AMICI, D</creatorcontrib><creatorcontrib>CASTELLAZZI, A. M</creatorcontrib><creatorcontrib>AUTELLI, M</creatorcontrib><creatorcontrib>BOTTINO, R</creatorcontrib><creatorcontrib>POLITO, E</creatorcontrib><creatorcontrib>BARTOLI, A</creatorcontrib><creatorcontrib>RONDINI, G</creatorcontrib><creatorcontrib>CHIRICO, G</creatorcontrib><title>Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates</title><title>Pediatric anesthesia</title><addtitle>Paediatr Anaesth</addtitle><description>Background: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity.
Methods: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C).
Results: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10.
Conclusions: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine‐immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia.</description><subject>Anesthesia, Epidural</subject><subject>Anesthesia, General</subject><subject>Anesthesia, Obstetrical</subject><subject>Anesthetics, Inhalation</subject><subject>Anesthetics, Local</subject><subject>Cesarean Section</subject><subject>Delivery, Obstetric</subject><subject>Humans</subject><subject>Infant, Newborn - immunology</subject><subject>Infant, Newborn - metabolism</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lidocaine</subject><subject>Methyl Ethers</subject><subject>mode of delivery</subject><subject>neutrophil function</subject><subject>Neutrophils - immunology</subject><subject>NK activity</subject><subject>Respiratory Burst</subject><subject>sevoflurane</subject><subject>thyroid hormones</subject><subject>Thyroid Hormones - metabolism</subject><issn>1155-5645</issn><issn>1460-9592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0E4v0LyCt2CR4_4kRigxAUJAQsQJXYWG5iU5c8ip2I9u9xSQVbVh5r7hmPD0IYSAqEZxeLFHhGkkIUNKWE0JQQKWi62kGHv43dWIMQici4OEBHISwIAUYzuo8OAHJeCCkP0fTGWlP2uLP43bTG6xrrtsJm6aphvGgT-rkJTuOuxf187TtX4Xnnm6414SfsmmZoXb_GrsWt6Vrdm3CC9qyugzndnsfo9fbm5foueXia3F9fPSQlJ5QmuTUzSwqZV1ZwKEFzTYVkJedASE5JUTFbCgkCpNQ0FwCZZDr2wRbc0pIdo_Nx7tJ3n0NcVTUulKauddxkCEoC5wwKFoP5GCx9F4I3Vi29a7RfKyBqI1Ut1Mad2rhTG6nqR6paRfRs-8Ywa0z1B24txsDlGPhytVn_e7B6vnqMRcSTEXehN6tfXPsPFX8rhZo-TlRO3hh7vpuoF_YNAE6T5w</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>GASPARONI, A</creator><creator>CIARDELLI, L</creator><creator>DE AMICI, D</creator><creator>CASTELLAZZI, A. M</creator><creator>AUTELLI, M</creator><creator>BOTTINO, R</creator><creator>POLITO, E</creator><creator>BARTOLI, A</creator><creator>RONDINI, G</creator><creator>CHIRICO, G</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates</title><author>GASPARONI, A ; CIARDELLI, L ; DE AMICI, D ; CASTELLAZZI, A. M ; AUTELLI, M ; BOTTINO, R ; POLITO, E ; BARTOLI, A ; RONDINI, G ; CHIRICO, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4022-8febf0978df541c1a4a2573c441008209d3fc5715177a28511673a3c41f94f2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthesia, Epidural</topic><topic>Anesthesia, General</topic><topic>Anesthesia, Obstetrical</topic><topic>Anesthetics, Inhalation</topic><topic>Anesthetics, Local</topic><topic>Cesarean Section</topic><topic>Delivery, Obstetric</topic><topic>Humans</topic><topic>Infant, Newborn - immunology</topic><topic>Infant, Newborn - metabolism</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lidocaine</topic><topic>Methyl Ethers</topic><topic>mode of delivery</topic><topic>neutrophil function</topic><topic>Neutrophils - immunology</topic><topic>NK activity</topic><topic>Respiratory Burst</topic><topic>sevoflurane</topic><topic>thyroid hormones</topic><topic>Thyroid Hormones - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GASPARONI, A</creatorcontrib><creatorcontrib>CIARDELLI, L</creatorcontrib><creatorcontrib>DE AMICI, D</creatorcontrib><creatorcontrib>CASTELLAZZI, A. M</creatorcontrib><creatorcontrib>AUTELLI, M</creatorcontrib><creatorcontrib>BOTTINO, R</creatorcontrib><creatorcontrib>POLITO, E</creatorcontrib><creatorcontrib>BARTOLI, A</creatorcontrib><creatorcontrib>RONDINI, G</creatorcontrib><creatorcontrib>CHIRICO, G</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GASPARONI, A</au><au>CIARDELLI, L</au><au>DE AMICI, D</au><au>CASTELLAZZI, A. M</au><au>AUTELLI, M</au><au>BOTTINO, R</au><au>POLITO, E</au><au>BARTOLI, A</au><au>RONDINI, G</au><au>CHIRICO, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates</atitle><jtitle>Pediatric anesthesia</jtitle><addtitle>Paediatr Anaesth</addtitle><date>2002-01</date><risdate>2002</risdate><volume>12</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>1155-5645</issn><eissn>1460-9592</eissn><abstract>Background: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity.
Methods: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C).
Results: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10.
Conclusions: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine‐immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11849577</pmid><doi>10.1046/j.1460-9592.2002.00752.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pediatric anesthesia, 2002-01, Vol.12 (1), p.59-64 |
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| subjects | Anesthesia, Epidural Anesthesia, General Anesthesia, Obstetrical Anesthetics, Inhalation Anesthetics, Local Cesarean Section Delivery, Obstetric Humans Infant, Newborn - immunology Infant, Newborn - metabolism Killer Cells, Natural - immunology Lidocaine Methyl Ethers mode of delivery neutrophil function Neutrophils - immunology NK activity Respiratory Burst sevoflurane thyroid hormones Thyroid Hormones - metabolism |
| title | Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates |
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