Helix peptide immunoreactivity pattern in the nervous system of juvenile aplysia

Distribution of neurons immunopositive to antibody against the small peptides encoded by the Helix Command-Specific 2 (HCS2) gene in the central nervous system of juvenile Aplysia californica was investigated. The HCS2 gene is specifically expressed in the withdrawal behavior neurons of the terrestr...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2003-12, Vol.120 (1), p.84-89
Main Authors: Ierusalimsky, V.N., Boguslavsky, D.V., Belyavsky, A.V., Balaban, P.M.
Format: Article
Language:English
Subjects:
Animals
Aplysia
Aplysia californica
Calcium-Binding Proteins - metabolism
Central Nervous System - cytology
Central Nervous System - metabolism
Ganglia, Invertebrate - cytology
Ganglia, Invertebrate - metabolism
HCS2 gene
HCS2 protein
Helix lucorum
Immunoblotting
Immunocytochemistry
Immunohistochemistry - methods
Marine
Neurons
Neurons - metabolism
Neuropeptides
Neuropeptides - immunology
Neuropeptides - metabolism
Protein Precursors - metabolism
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Summary:Distribution of neurons immunopositive to antibody against the small peptides encoded by the Helix Command-Specific 2 (HCS2) gene in the central nervous system of juvenile Aplysia californica was investigated. The HCS2 gene is specifically expressed in the withdrawal behavior neurons of the terrestrial snail Helix lucorum. In Aplysia, 20–25 immunopositive neuronal somata were observed on dorsal surface of each pleural ganglion (including a giant pleural neuron). The HCS2-encoded peptide immunopositive fibers were observed in neuropiles of all ganglia and in many nerves. Functional significance of Aplysia immunopositive cells is discussed.
ISSN:0169-328X
1872-6941
DOI:10.1016/j.molbrainres.2003.10.007