A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy

The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epile...

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Bibliographic Details
Published in:Annals of neurology 2002-02, Vol.51 (2), p.260-263
Main Authors: Stögmann, Elisabeth, Zimprich, Alexander, Baumgartner, Christoph, Aull-Watschinger, Susanne, Höllt, Volker, Zimprich, Fritz
Format: Article
Language:English
Subjects:
Biological and medical sciences
Enkephalins - genetics
Epilepsy, Temporal Lobe - epidemiology
Epilepsy, Temporal Lobe - genetics
Female
Genetic Predisposition to Disease
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Protein Precursors - genetics
Risk Factors
Severity of Illness Index
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Summary:The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epilepsy and 202 controls and found that PDYN promotor low‐expression L‐alleles confer an increased risk for temporal lobe epilepsy in patients with a family history for seizures. Irrespective of the familial background, L‐homozygotes display a higher risk for secondarily generalized seizures and status epilepticus.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.10108