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Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals

In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesi...

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Published in:Phytotherapy research 2003-12, Vol.17 (10), p.1188-1194
Main Authors: Han, Li-Kun, Sumiyoshi, Maho, Zhang, Jing, Liu, Mo-Xiang, Zhang, Xin-Feng, Zheng, Yi-Nan, Okuda, Hiromichi, Kimura, Yoshiyuki
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creator Han, Li-Kun
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description In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high‐fat diet to female mice for 9 weeks. Body weights at 2–9 weeks and the final parametrial adipose tissue weights were significantly lower in mice fed the high‐fat diet with 5% polyphenols of S. matsudana leaves than in those fed the high‐fat diet alone. The polyphenols of S. matsudana leaves also significantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high‐fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and α‐amylase activity, and their fractions enhanced norepinephrine‐induced lipolysis in fat cells. In conclusion, it is suggested that the inhibitory effects of the flavonoid glycoside fraction of S. matsudana leaves on high‐fat diet‐induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of α‐amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine‐induced lipolysis in fat cells. Copyright © 2003 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/ptr.1404
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Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Han, Li-Kun ; Sumiyoshi, Maho ; Zhang, Jing ; Liu, Mo-Xiang ; Zhang, Xin-Feng ; Zheng, Yi-Nan ; Okuda, Hiromichi ; Kimura, Yoshiyuki</creator><creatorcontrib>Han, Li-Kun ; Sumiyoshi, Maho ; Zhang, Jing ; Liu, Mo-Xiang ; Zhang, Xin-Feng ; Zheng, Yi-Nan ; Okuda, Hiromichi ; Kimura, Yoshiyuki</creatorcontrib><description>In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high‐fat diet to female mice for 9 weeks. Body weights at 2–9 weeks and the final parametrial adipose tissue weights were significantly lower in mice fed the high‐fat diet with 5% polyphenols of S. matsudana leaves than in those fed the high‐fat diet alone. The polyphenols of S. matsudana leaves also significantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high‐fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and α‐amylase activity, and their fractions enhanced norepinephrine‐induced lipolysis in fat cells. In conclusion, it is suggested that the inhibitory effects of the flavonoid glycoside fraction of S. matsudana leaves on high‐fat diet‐induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of α‐amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine‐induced lipolysis in fat cells. Copyright © 2003 John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1404</identifier><identifier>PMID: 14669254</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Adipocytes - drug effects ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; Anti-Obesity Agents - administration &amp; dosage ; Anti-Obesity Agents - pharmacology ; Anti-Obesity Agents - therapeutic use ; Biological and medical sciences ; Body Weight ; brush border membrane vesicles ; Cholesterol - metabolism ; Diet ; Dietary Fats ; Disease Models, Animal ; Feces ; Female ; Flavonoids - administration &amp; dosage ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; General pharmacology ; high-fat diet ; Jejunum - drug effects ; Lipolysis - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Norepinephrine ; Obesity - prevention &amp; control ; parametrial adipose tissue weight ; Pharmacognosy. 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Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high‐fat diet to female mice for 9 weeks. Body weights at 2–9 weeks and the final parametrial adipose tissue weights were significantly lower in mice fed the high‐fat diet with 5% polyphenols of S. matsudana leaves than in those fed the high‐fat diet alone. The polyphenols of S. matsudana leaves also significantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high‐fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and α‐amylase activity, and their fractions enhanced norepinephrine‐induced lipolysis in fat cells. In conclusion, it is suggested that the inhibitory effects of the flavonoid glycoside fraction of S. matsudana leaves on high‐fat diet‐induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of α‐amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine‐induced lipolysis in fat cells. 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Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2003-12</date><risdate>2003</risdate><volume>17</volume><issue>10</issue><spage>1188</spage><epage>1194</epage><pages>1188-1194</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high‐fat diet to female mice for 9 weeks. 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In conclusion, it is suggested that the inhibitory effects of the flavonoid glycoside fraction of S. matsudana leaves on high‐fat diet‐induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of α‐amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine‐induced lipolysis in fat cells. Copyright © 2003 John Wiley &amp; Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>14669254</pmid><doi>10.1002/ptr.1404</doi><tpages>7</tpages></addata></record>
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identifier ISSN: 0951-418X
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subjects Adipocytes - drug effects
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Animals
Anti-Obesity Agents - administration & dosage
Anti-Obesity Agents - pharmacology
Anti-Obesity Agents - therapeutic use
Biological and medical sciences
Body Weight
brush border membrane vesicles
Cholesterol - metabolism
Diet
Dietary Fats
Disease Models, Animal
Feces
Female
Flavonoids - administration & dosage
Flavonoids - pharmacology
Flavonoids - therapeutic use
General pharmacology
high-fat diet
Jejunum - drug effects
Lipolysis - drug effects
Liver - drug effects
Liver - metabolism
Male
Medical sciences
Mice
Mice, Inbred ICR
Norepinephrine
Obesity - prevention & control
parametrial adipose tissue weight
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - administration & dosage
Phenols - pharmacology
Phenols - therapeutic use
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Polyphenols
Rats
Rats, Wistar
Salix
Salix matsudana
Triglycerides - metabolism
α-amylase activity
title Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals
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