Fibrous meningeal tumours with extensive non-calcifying collagenous whorls and glial fibrillary acidic protein expression: the whorling-sclerosing variant of meningioma

Meningiomas comprise a wide range of morphological patterns. We describe unusual fibrous meningeal tumours in two patients, composed of extensive non‐calcifying collagenous whorls of varying size, resembling non‐calcified psammoma bodies, while interposed tumour cells are sparse. Immunohistochemistr...

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Bibliographic Details
Published in:Neuropathology and applied neurobiology 2002-02, Vol.28 (1), p.42-47
Main Authors: Haberler, C., Jarius, C., Lang, S., Rössler, K., Gruber, A., Hainfellner, J. A., Budka, H.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Collagen - analysis
Diagnosis, Differential
electron microscopy
Female
glial fibrillary acidic protein
Glial Fibrillary Acidic Protein - analysis
Humans
immunohistochemistry
Magnetic Resonance Imaging
Male
Medical sciences
Meningeal Neoplasms - chemistry
Meningeal Neoplasms - pathology
meningioma
Meningioma - chemistry
Meningioma - pathology
Microscopy, Electron
Middle Aged
Neurology
Tumors of the nervous system. Phacomatoses
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Summary:Meningiomas comprise a wide range of morphological patterns. We describe unusual fibrous meningeal tumours in two patients, composed of extensive non‐calcifying collagenous whorls of varying size, resembling non‐calcified psammoma bodies, while interposed tumour cells are sparse. Immunohistochemistry showed expression of S‐100, vimentin and glial fibrillary acidic protein, whereas only single tumour cells stained for epithelial membrane antigen. Electron microscopy detected desmosomes or desmosome‐like structures in both specimens. We conclude that these tumours represent a peculiar whorling‐sclerosing variant of fibrous meningioma. Recognition of this meningioma variant is important in the differential diagnosis of meningioma versus other fibrous tumours of the meninges, including solitary fibrous tumours of the meninges, unusual forms of desmoplastic gliomas or chondroid tumours.
ISSN:0305-1846
1365-2990
DOI:10.1046/j.0305-1846.2001.00364.x