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Extending the golden hour of hemorrhagic shock tolerance with oxygen plus hypothermia in awake rats.: An exploratory study

In a previous study of volume-controlled hemorrhagic shock (HS) in awake rats, without fluid resuscitation, either breathing of 100% oxygen or moderate hypothermia while breathing air, increased survival time. We hypothesized that combining oxygen and hypothermia can maximally extend the ‘golden hou...

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Bibliographic Details
Published in:Resuscitation 2002-02, Vol.52 (2), p.193-202
Main Authors: Leonov, Yuval, Safar, Peter, Sterz, Fritz, Stezoski, S.William
Format: Article
Language:English
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Summary:In a previous study of volume-controlled hemorrhagic shock (HS) in awake rats, without fluid resuscitation, either breathing of 100% oxygen or moderate hypothermia while breathing air, increased survival time. We hypothesized that combining oxygen and hypothermia can maximally extend the ‘golden hour’ of HS from which resuscitation can be successful in terms of survival rate. Rats were prepared under light general anesthesia, breathing spontaneously via face mask, and then awakened for 2 h. Then, 3.25 ml arterial blood/100 g were withdrawn over 20 min. At the end of HS of 30, 60, 90 or 180 min duration, the shed blood was reinfused. Breathing was spontaneous. Survival endpoint was 24 h or earlier death. HS of 30 or 60 min was used for preliminary experiments; HS of 90 or 180 min for 35 definitive experiments. Control groups A-1 and B-1 had normothermia (rectal temperature 37.5 °C) and were breathing air. Treatment groups A-2 and B-2 had total body surface cooling during HS to rectal temperature 32 °C and were breathing 100% O 2. Arterial pressure during HS was higher in the hypothermia–O 2 groups. With HS of 90 min, in the normothermia–air group A-1 ( n=10), none of the 10 rats survived to 3 h; while in the hypothermia–O 2 group A-2 ( n=5), all rats survived to 24 h ( P
ISSN:0300-9572
1873-1570
DOI:10.1016/S0300-9572(01)00453-1