Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model

Purpose To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease. Materials and Methods Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenze...

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Published in:Journal of magnetic resonance imaging 2002-02, Vol.15 (2), p.165-173
Main Authors: Knollmann, Friedrich D., Dietrich, Thore, Bleckmann, Tim, Böck, Johannes, Mäurer, Jürgen, Radtke, Cornelia, Felix, Roland
Format: Article
Language:English
Subjects:
Animals
Contrast Media
contrast media, magnetic resonance
enteritis
experimental studies
Gadolinium DTPA
Inflammatory Bowel Diseases - pathology
intestines
intestines, magnetic resonance
magnetic resonance
Magnetic Resonance Imaging - methods
magnetic resonance, experimental studies
Models, Animal
Rabbits
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Summary:Purpose To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease. Materials and Methods Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis. Results MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease (P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04). Conclusion Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.10054