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Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model
Purpose To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease. Materials and Methods Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenze...
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| Published in: | Journal of magnetic resonance imaging 2002-02, Vol.15 (2), p.165-173 |
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| cited_by | cdi_FETCH-LOGICAL-c3994-e2177401732cb0c162189df130b935c5aea693dadfa6ff399f864cfc78e528bd3 |
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| cites | cdi_FETCH-LOGICAL-c3994-e2177401732cb0c162189df130b935c5aea693dadfa6ff399f864cfc78e528bd3 |
| container_end_page | 173 |
| container_issue | 2 |
| container_start_page | 165 |
| container_title | Journal of magnetic resonance imaging |
| container_volume | 15 |
| creator | Knollmann, Friedrich D. Dietrich, Thore Bleckmann, Tim Böck, Johannes Mäurer, Jürgen Radtke, Cornelia Felix, Roland |
| description | Purpose
To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease.
Materials and Methods
Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis.
Results
MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease (P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04).
Conclusion
Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.10054 |
| format | article |
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To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease.
Materials and Methods
Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis.
Results
MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease (P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04).
Conclusion
Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.10054</identifier><identifier>PMID: 11836772</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Contrast Media ; contrast media, magnetic resonance ; enteritis ; experimental studies ; Gadolinium DTPA ; Inflammatory Bowel Diseases - pathology ; intestines ; intestines, magnetic resonance ; magnetic resonance ; Magnetic Resonance Imaging - methods ; magnetic resonance, experimental studies ; Models, Animal ; Rabbits</subject><ispartof>Journal of magnetic resonance imaging, 2002-02, Vol.15 (2), p.165-173</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>Copyright 2002 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3994-e2177401732cb0c162189df130b935c5aea693dadfa6ff399f864cfc78e528bd3</citedby><cites>FETCH-LOGICAL-c3994-e2177401732cb0c162189df130b935c5aea693dadfa6ff399f864cfc78e528bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11836772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knollmann, Friedrich D.</creatorcontrib><creatorcontrib>Dietrich, Thore</creatorcontrib><creatorcontrib>Bleckmann, Tim</creatorcontrib><creatorcontrib>Böck, Johannes</creatorcontrib><creatorcontrib>Mäurer, Jürgen</creatorcontrib><creatorcontrib>Radtke, Cornelia</creatorcontrib><creatorcontrib>Felix, Roland</creatorcontrib><title>Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease.
Materials and Methods
Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis.
Results
MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease (P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04).
Conclusion
Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Contrast Media</subject><subject>contrast media, magnetic resonance</subject><subject>enteritis</subject><subject>experimental studies</subject><subject>Gadolinium DTPA</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>intestines</subject><subject>intestines, magnetic resonance</subject><subject>magnetic resonance</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>magnetic resonance, experimental studies</subject><subject>Models, Animal</subject><subject>Rabbits</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhq0KVGDbCz-g8okDUsAfcZz0hlbAUkE_EC1Ha-KMV6ZJDHYW2H9PtruUG6eZw_O-mnkI2efsiDMmju-66Febyj-QXa6EyIQqi61xZ0pmvGR6h-yldMcYq6pcfSQ7nJey0Frskj9XMO9x8JZGTKGH3iL1Hcx9P6fBUd-7FroOhhCXtA5P2NLGJ4SEX-npI7QLGHzoR4wCjVDXfqBdaLD9RLYdtAk_b-aE_D47vZnOsssf5xfTk8vMyvGUDAXXOmdcS2FrZnkheFk1jktWV1JZBQhFJRtoHBTOjRFXFrl1VpeoRFk3ckIO1r33MTwsMA2m88li20KPYZGM5rkSRalG8HAN2hhSiujMfRz_jEvDmVlZNCuL5p_FEf6yaV3UHTZv6EbbCPA18ORbXL5TZb5dXV-8lmbrjE8DPv_PQPxrCi21Mrffz83Nz-tfM8GnRsgXHGOMbg</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Knollmann, Friedrich D.</creator><creator>Dietrich, Thore</creator><creator>Bleckmann, Tim</creator><creator>Böck, Johannes</creator><creator>Mäurer, Jürgen</creator><creator>Radtke, Cornelia</creator><creator>Felix, Roland</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model</title><author>Knollmann, Friedrich D. ; Dietrich, Thore ; Bleckmann, Tim ; Böck, Johannes ; Mäurer, Jürgen ; Radtke, Cornelia ; Felix, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3994-e2177401732cb0c162189df130b935c5aea693dadfa6ff399f864cfc78e528bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Contrast Media</topic><topic>contrast media, magnetic resonance</topic><topic>enteritis</topic><topic>experimental studies</topic><topic>Gadolinium DTPA</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>intestines</topic><topic>intestines, magnetic resonance</topic><topic>magnetic resonance</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>magnetic resonance, experimental studies</topic><topic>Models, Animal</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knollmann, Friedrich D.</creatorcontrib><creatorcontrib>Dietrich, Thore</creatorcontrib><creatorcontrib>Bleckmann, Tim</creatorcontrib><creatorcontrib>Böck, Johannes</creatorcontrib><creatorcontrib>Mäurer, Jürgen</creatorcontrib><creatorcontrib>Radtke, Cornelia</creatorcontrib><creatorcontrib>Felix, Roland</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knollmann, Friedrich D.</au><au>Dietrich, Thore</au><au>Bleckmann, Tim</au><au>Böck, Johannes</au><au>Mäurer, Jürgen</au><au>Radtke, Cornelia</au><au>Felix, Roland</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2002-02</date><risdate>2002</risdate><volume>15</volume><issue>2</issue><spage>165</spage><epage>173</epage><pages>165-173</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease.
Materials and Methods
Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis.
Results
MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease (P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04).
Conclusion
Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>11836772</pmid><doi>10.1002/jmri.10054</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2002-02, Vol.15 (2), p.165-173 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Contrast Media contrast media, magnetic resonance enteritis experimental studies Gadolinium DTPA Inflammatory Bowel Diseases - pathology intestines intestines, magnetic resonance magnetic resonance Magnetic Resonance Imaging - methods magnetic resonance, experimental studies Models, Animal Rabbits |
| title | Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model |
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