Detection of HCV RNA in saliva of patients with hepatitis C virus infection by using a highly sensitive test

Hepatitis C virus (HCV) is transmitted primarily by direct percutaneous exposures to blood. Since HCV RNA has been found in saliva, it has been suggested that saliva might also be a source of infection. HCV RNA in saliva from plasma HCV RNA positive patients was tested by a highly sensitive PCR meth...

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Bibliographic Details
Published in:Journal of virological methods 2002-03, Vol.101 (1), p.29-35
Main Authors: Hermida, M, Ferreiro, M.C, Barral, S, Laredo, R, Castro, A, Diz Dios, P
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Disease transmission
Female
Fundamental and applied biological sciences. Psychology
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C - transmission
Hepatitis C virus
Humans
Male
Microbiology
Middle Aged
Polymerase chain reaction
Polymerase Chain Reaction - methods
Risk Factors
RNA, Viral - analysis
RNA, Viral - blood
Saliva
Saliva - virology
Sensitivity and Specificity
Spain - epidemiology
Techniques used in virology
Time Factors
Viral Load
Virology
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Summary:Hepatitis C virus (HCV) is transmitted primarily by direct percutaneous exposures to blood. Since HCV RNA has been found in saliva, it has been suggested that saliva might also be a source of infection. HCV RNA in saliva from plasma HCV RNA positive patients was tested by a highly sensitive PCR method. HCV RNA was detected in 32 out of 61 saliva specimens (52.4%). No correlation was found between the presence of HCV in saliva and age, sex, identified risk factors for HCV infection, time lapsed since the diagnosis, transaminases and alkaline phosphatase values and stimulated salivary flow. A statistically significant relation between plasma HCV RNA viral load and saliva HCV RNA detection was observed ( P
ISSN:0166-0934
1879-0984
DOI:10.1016/S0166-0934(01)00417-7