Electrophysiological abnormalities of the atrial muscle in patients with paroxysmal atrial fibrillation associated with hyperthyroidism

Summary objective Atrial fibrillation (AF) is common in patients with hyperthyroidism. Although the choice of an antiarrhythmic agent should be based on its electrophysiological effects and the electrophysiological properties of the arrhythmia in question, the atrial electrophysiological features of...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2002-01, Vol.56 (1), p.39-44
Main Authors: Komiya, Norihiro, Isomoto, Shojiro, Nakao, Kojiro, Hayano, Motonobu, Yano, Katsusuke
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Atrial Function
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Electric Stimulation
Electrocardiography
Endocrinopathies
Heart
Heart - physiopathology
Humans
Hyperthyroidism - complications
Hyperthyroidism - physiopathology
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid Function Tests
Thyroid. Thyroid axis (diseases)
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Summary:Summary objective Atrial fibrillation (AF) is common in patients with hyperthyroidism. Although the choice of an antiarrhythmic agent should be based on its electrophysiological effects and the electrophysiological properties of the arrhythmia in question, the atrial electrophysiological features of AF associated with hyperthyroidism are unknown. The purposes of this study are to clarify the atrial electrophysiological abnormalities of AF with hyperthyroidism, and to propose effective therapies for AF in patients with hyperthyroidism. subjects and design This study included 117 patients who underwent electrophysiological study and were evaluated for thyroid function: 29 patients without AF or hyperthyroidism (Group I), 78 patients with lone paroxysmal AF (Group II), and 10 patients with paroxysmal AF and hyperthyroidism (Group III). The following electrophysiological parameters were assessed and measured quantitatively: (1) the incidence of abnormal right atrial electrograms during sinus rhythm, indicating areas of altered anatomy and conduction where AF is likely to develop; (2) the atrial effective refractory period (ERP); and (3) the atrial conduction delay (CD), which is induced by early atrial premature beats close to the atrial ERP and is thought to facilitate the occurrence of AF. results The incidence of abnormal right atrial electrograms during sinus rhythm was significantly higher in Group II (67·1%) than in Group I (20·0%, P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.0300-0664.2001.01459.x