Spectrum of mutations in BRCA1 gene in hereditary forms of breast and ovarian cancer in Russian families

The 5382insC mutation predominated (94%) in the spectrum of detected mutations of BRCA1 gene. High incidence of this mutation in familial breast cancer detected for the first time attested to origination of 5382insC mutation from the European part of Russia. The percentage of families with mutations...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-09, Vol.136 (3), p.276-278
Main Authors: Loginova, A N, Pospekhova, N I, Lyubchenko, L N, Budilov, A V, Zakhar'ev, V M, Gar'kavtseva, R F, Ginter, E K, Karpukhin, A V
Format: Article
Language:English
Subjects:
BRCA1 Protein - genetics
Breast Neoplasms - genetics
Family Health
Female
Genes, BRCA1
Genetic Predisposition to Disease - genetics
Humans
Mutation
Ovarian cancer
Ovarian Neoplasms - genetics
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Summary:The 5382insC mutation predominated (94%) in the spectrum of detected mutations of BRCA1 gene. High incidence of this mutation in familial breast cancer detected for the first time attested to origination of 5382insC mutation from the European part of Russia. The percentage of families with mutations in BRCA1 gene and familial predisposition to ovarian cancer was significantly higher than in hereditary predisposition to breast cancer (p
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000008982.21806.9b