The efficacy of intra-articular sodium hyaluronate in patients with reducing displaced disc of the temporomandibular joint

• Published in: Journal of oral rehabilitation 2002-01, Vol.29 (1), p.80-86
• Main Authors: Hepguler, S., Akkoc, Y. S., Pehlivan, M., Ozturk, C., Celebi, G., Saracoglu, A., Ozpinar, B.
• Format: Article
• Language: English
• Subjects: Adult; Chi-Square Distribution; Dentistry; Double-Blind Method; Facial Pain - drug therapy; Facial Pain - physiopathology; Female; Follow-Up Studies; Humans; Hyaluronic Acid - administration & dosage; Hyaluronic Acid - therapeutic use; Injections, Intra-Articular; intra-articular therapy; Joint Dislocations - drug therapy; Joint Dislocations - physiopathology; Male; Pain Measurement; Placebos; Range of Motion, Articular - physiology; Remission Induction; Signal Processing, Computer-Assisted; Sodium Chloride; sodium hyaluronate (hyaluronan); Sound; temporomandibular joint; Temporomandibular Joint Disc - drug effects; Temporomandibular Joint Disc - physiopathology; Treatment Outcome; Vibration
• ISSN: 0305-182X; 1365-2842
• DOI: 10.1046/j.1365-2842.2002.00807.x

In this clinical trial, we examined the efficacy of intra‐articular hyaluronic acid (HA) treatment in 38 patients with reducing displaced disc of the temporomandibular joint (TMJ). Subjects received two unilateral upper space injections of HA or physiological saline solution with 1 week apart. Efficacy was based on the following measurements: pain and sound intensity of the joint measured by visual analogue scale (VAS), modified Helkimo’s clinical dysfunction index and the intensity of joint vibration during opening and closing the mouth measured by accelerometers. These measurements were performed before the first injection and 1 and 6 months after the last injection. In the treatment group (n=19), all measurements improved significantly at month 1 and at month 6 compared with the baseline (P