Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice

Background: Increasing use of transgenic and gene targeting techniques for the investigation of hemostasis and vascular biology has generated interest in experimental models of carotid artery thrombosis in mice. Objectives: We tested the hypothesis that hypoventilation in anesthetized mice may cause...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2003-12, Vol.1 (12), p.2669-2674
Main Authors: Wilson, K. M., Lynch, C. M., Faraci, F. M., Lentz, S. R.
Format: Article
Language:English
Subjects:
Anesthesia - adverse effects
Animals
Blood Gas Analysis
carotid artery
Carotid Artery Diseases - etiology
Carotid Artery Injuries
Hypercapnia - etiology
injury
Mice
Mice, Inbred Strains
Photochemistry
Regional Blood Flow
Respiration, Artificial - adverse effects
thrombosis
Thrombosis - etiology
transgenic
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Summary:Background: Increasing use of transgenic and gene targeting techniques for the investigation of hemostasis and vascular biology has generated interest in experimental models of carotid artery thrombosis in mice. Objectives: We tested the hypothesis that hypoventilation in anesthetized mice may cause hypercapnia, increased carotid artery blood flow, and altered thrombotic responses to photochemical injury of the carotid artery. Methods: Arterial blood gases and carotid artery blood flow were measured in pentobarbital‐anesthetized BALB/c or C57BL/6 J mice with and without mechanical ventilation. Photochemical injury of the carotid artery was induced using the rose bengal method. Results: Compared with ventilated mice, unventilated mice had a 45% increase in carotid artery blood flow (0.74 ± 0.04 vs. 0.41 ± 0.03 mL min−1; P 
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2003.00482.x