Semiconductor Quantum Dots for Photodynamic Therapy

The applicability of semiconductor QDs in photodynamic therapy (PDT) was evaluated by studying the interaction between CdSe QDs with a known silicon phthalocyanine PDT photosensitizer, Pc4. The study revealed that the QDs could be used to sensitize the PDT agent through a fluorescence resonance ener...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2003-12, Vol.125 (51), p.15736-15737
Main Authors: Samia, Anna C. S, Chen, Xiaobo, Burda, Clemens
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cadmium Compounds - chemistry
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Exact sciences and technology
Fluorescence Resonance Energy Transfer
Indoles - chemistry
Medical sciences
Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation
Optical properties of low-dimensional, mesoscopic, and nanoscale materials and structures
Oxygen - chemistry
Photochemotherapy
Photoradiation therapy and photosensitizing agent
Photosensitizing Agents - chemistry
Physics
Quantum Dots
Selenium Compounds - chemistry
Semiconductors
Treatment with physical agents
Treatment. General aspects
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The applicability of semiconductor QDs in photodynamic therapy (PDT) was evaluated by studying the interaction between CdSe QDs with a known silicon phthalocyanine PDT photosensitizer, Pc4. The study revealed that the QDs could be used to sensitize the PDT agent through a fluorescence resonance energy transfer (FRET) mechanism, or interact directly with molecular oxygen via a triplet energy-transfer process (TET). Both mechanisms result in the generation of reactive singlet oxygen species that can be used for PDT cancer therapy.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0386905