Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers

Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given t...

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Bibliographic Details
Published in:Oral oncology 2002-02, Vol.38 (2), p.201-208
Main Authors: Nikitakis, Nikolaos G, Lopes, Marcio A, Bailey, Jonathan S, Blanchaert Jr, Remy H, Ord, Robert A, Sauk, John J
Format: Article
Language:English
Subjects:
Adult
bcl-2
Biological and medical sciences
Biomarkers, Tumor - analysis
CDK4
Female
Gingival Neoplasms - diagnosis
Gingival Neoplasms - pathology
Humans
Immunohistochemistry
Leiomyosarcoma
Leiomyosarcoma - diagnosis
Leiomyosarcoma - pathology
Male
Mandibular Neoplasms - diagnosis
Mandibular Neoplasms - pathology
MDM2
Medical sciences
Middle Aged
Oral
Otorhinolaryngology. Stomatology
p53
PCNA
Prognosis
Real-time quantitative PCR
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(01)00047-1