The human frizzled-3 ( FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia

Neurodevelopmental abnormalities have been reported in studies on the pathogenesis of schizophrenia. The Wnt-signaling pathway has been implicated in a variety of processes in neurodevelopment, and the frizzled proteins have been identified as receptors for Wnt ligands. Of the frizzled proteins, fri...

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Bibliographic Details
Published in:Neuroscience letters 2003-12, Vol.353 (1), p.53-56
Main Authors: Katsu, Takeshi, Ujike, Hiroshi, Nakano, Takamitsu, Tanaka, Yuji, Nomura, Akira, Nakata, Kenji, Takaki, Manabu, Sakai, Ayumu, Uchida, Naohiko, Imamura, Takaki, Kuroda, Shigetoshi
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Association study
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
Chromosome 8p21
Chromosome Mapping
Chromosomes, Human, Pair 8
Female
Frizzled Receptors
FZD3
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Japanese
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction - methods
Polymorphism, Single Nucleotide
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptors, G-Protein-Coupled - genetics
Schizophrenia
Schizophrenia - classification
Schizophrenia - genetics
Signal Transduction - genetics
Wnt
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Summary:Neurodevelopmental abnormalities have been reported in studies on the pathogenesis of schizophrenia. The Wnt-signaling pathway has been implicated in a variety of processes in neurodevelopment, and the frizzled proteins have been identified as receptors for Wnt ligands. Of the frizzled proteins, frizzled-3 (FZD3) is required for formation of the neural crest and for development of major fiber tracts in the CNS. The human FZD3 gene is located on chromosome 8p21, a positive linkage locus for schizophrenia. We analyzed polymorphisms of the FZD3 gene in patients with schizophrenia and control subjects in the Japanese population. We found a significant association between schizophrenia and the FZD3 gene in single nucleotide polymorphisms and haplotype analyses. Our data suggest that dysregulation of the Wnt-signaling pathway may be involved in the susceptibility to schizophrenia.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2003.09.017