Low Vitamin D and High Parathyroid Hormone Levels as Determinants of Loss of Muscle Strength and Muscle Mass (Sarcopenia): The Longitudinal Aging Study Amsterdam

The age-related change in hormone concentrations has been hypothesized to play a role in the loss of muscle mass and muscle strength with aging, also called sarcopenia. The aim of this prospective study was to investigate whether low serum 25-hydroxyvitamin D (25-OHD) and high serum PTH concentratio...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2003-12, Vol.88 (12), p.5766-5772
Main Authors: Visser, Marjolein, Deeg, Dorly J. H., Lips, Paul
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Aged
Aged, 80 and over
Aging
Analysis. Health state
Biological and medical sciences
Cohort Studies
Epidemiology
Female
General aspects
Hand Strength
Humans
Longitudinal Studies
Male
Medical sciences
Muscle, Skeletal - physiopathology
Muscle, Skeletal - radiation effects
Nervous system involvement in other diseases. Miscellaneous
Neurology
Odds Ratio
Osmolar Concentration
Parathyroid Hormone - blood
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:The age-related change in hormone concentrations has been hypothesized to play a role in the loss of muscle mass and muscle strength with aging, also called sarcopenia. The aim of this prospective study was to investigate whether low serum 25-hydroxyvitamin D (25-OHD) and high serum PTH concentration were associated with sarcopenia. In men and women aged 65 yr and older, participants of the Longitudinal Aging Study Amsterdam, grip strength (n = 1008) and appendicular skeletal muscle mass (n = 331, using dual-energy x-ray absorptiometry) were measured in 1995–1996 and after a 3-yr follow-up. Sarcopenia was defined as the lowest sex-specific 15th percentile of the cohort, translating into a loss of grip strength greater than 40% or a loss of muscle mass greater than 3%. After adjustment for physical activity level, season of data collection, serum creatinine concentration, chronic disease, smoking, and body mass index, persons with low (50 nmol/liter) levels. High PTH levels (≥4.0 pmol/liter) were associated with an increased risk of sarcopenia, compared with low PTH (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2003-030604