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Effect of Tablet Splitting on Serum Cholesterol Concentrations
OBJECTIVE: To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin. DESIGN: A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simva...
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| Published in: | The Annals of pharmacotherapy 2002-02, Vol.36 (2), p.205-209 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604093 |
| container_end_page | 209 |
| container_issue | 2 |
| container_start_page | 205 |
| container_title | The Annals of pharmacotherapy |
| container_volume | 36 |
| creator | Duncan, Megan C Castle, Sharon S Streetman, Daniel S |
| description | OBJECTIVE:
To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
DESIGN:
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
SETTING:
Veterans Affairs Medical Center in Huntington, WV.
PATIENTS:
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6–8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level >400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes.
MEASUREMENT OUTCOMES:
The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
RESULTS:
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
CONCLUSIONS:
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center. |
| doi_str_mv | 10.1345/aph.1A233 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71465573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1345_aph.1A233</sage_id><sourcerecordid>71465573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604093</originalsourceid><addsrcrecordid>eNptkDtPwzAUhS0EoqUw8AdQFpAYUvyMkwWpispDqsTQMkeOc9OmSuxiOwP_nkAjdWG6d_h0ztGH0C3Bc8K4eFKH3ZwsKGNnaEoEp3FCJT4ffpzgGNMUT9CV93uMcUZodokmhKRcZkxM0fOyrkGHyNbRRpUthGh9aJsQGrONrInW4Pouyne2BR_A2TbKrdFgglOhscZfo4tatR5uxjtDny_LTf4Wrz5e3_PFKtaM0xDXALLiTGcEiMRaUCqzKtUC1wyg1LpMSZKlZVUSDKkmQjGluGScsTLBHGdshh6OuQdnv_phS9E1XkPbKgO294UkPBFCsgF8PILaWe8d1MXBNZ1y3wXBxa-sYpBV_Mka2LsxtC87qE7kaGcA7kdAea3a2imjG3_iGJecSnJa59UWir3tnRlk_NP4A6DcfYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71465573</pqid></control><display><type>article</type><title>Effect of Tablet Splitting on Serum Cholesterol Concentrations</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>Duncan, Megan C ; Castle, Sharon S ; Streetman, Daniel S</creator><creatorcontrib>Duncan, Megan C ; Castle, Sharon S ; Streetman, Daniel S</creatorcontrib><description>OBJECTIVE:
To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
DESIGN:
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
SETTING:
Veterans Affairs Medical Center in Huntington, WV.
PATIENTS:
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6–8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level >400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes.
MEASUREMENT OUTCOMES:
The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
RESULTS:
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
CONCLUSIONS:
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.1A233</identifier><identifier>PMID: 11847935</identifier><identifier>CODEN: APHRER</identifier><language>eng</language><publisher>Cincinnati, OH: SAGE Publications</publisher><subject>Atorvastatin Calcium ; Biological and medical sciences ; Cholesterol - blood ; Cholesterol, LDL - blood ; Cross-Over Studies ; Drug Costs ; Female ; General and cellular metabolism. Vitamins ; Heptanoic Acids - administration & dosage ; Heptanoic Acids - economics ; Heptanoic Acids - pharmacology ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Pyrroles - administration & dosage ; Pyrroles - economics ; Pyrroles - pharmacology ; Retrospective Studies ; Simvastatin - administration & dosage ; Simvastatin - economics ; Simvastatin - pharmacology ; Tablets ; West Virginia</subject><ispartof>The Annals of pharmacotherapy, 2002-02, Vol.36 (2), p.205-209</ispartof><rights>2002 SAGE Publications</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604093</citedby><cites>FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13474271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11847935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duncan, Megan C</creatorcontrib><creatorcontrib>Castle, Sharon S</creatorcontrib><creatorcontrib>Streetman, Daniel S</creatorcontrib><title>Effect of Tablet Splitting on Serum Cholesterol Concentrations</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>OBJECTIVE:
To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
DESIGN:
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
SETTING:
Veterans Affairs Medical Center in Huntington, WV.
PATIENTS:
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6–8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level >400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes.
MEASUREMENT OUTCOMES:
The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
RESULTS:
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
CONCLUSIONS:
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center.</description><subject>Atorvastatin Calcium</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cross-Over Studies</subject><subject>Drug Costs</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heptanoic Acids - administration & dosage</subject><subject>Heptanoic Acids - economics</subject><subject>Heptanoic Acids - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrroles - administration & dosage</subject><subject>Pyrroles - economics</subject><subject>Pyrroles - pharmacology</subject><subject>Retrospective Studies</subject><subject>Simvastatin - administration & dosage</subject><subject>Simvastatin - economics</subject><subject>Simvastatin - pharmacology</subject><subject>Tablets</subject><subject>West Virginia</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNptkDtPwzAUhS0EoqUw8AdQFpAYUvyMkwWpispDqsTQMkeOc9OmSuxiOwP_nkAjdWG6d_h0ztGH0C3Bc8K4eFKH3ZwsKGNnaEoEp3FCJT4ffpzgGNMUT9CV93uMcUZodokmhKRcZkxM0fOyrkGHyNbRRpUthGh9aJsQGrONrInW4Pouyne2BR_A2TbKrdFgglOhscZfo4tatR5uxjtDny_LTf4Wrz5e3_PFKtaM0xDXALLiTGcEiMRaUCqzKtUC1wyg1LpMSZKlZVUSDKkmQjGluGScsTLBHGdshh6OuQdnv_phS9E1XkPbKgO294UkPBFCsgF8PILaWe8d1MXBNZ1y3wXBxa-sYpBV_Mka2LsxtC87qE7kaGcA7kdAea3a2imjG3_iGJecSnJa59UWir3tnRlk_NP4A6DcfYA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Duncan, Megan C</creator><creator>Castle, Sharon S</creator><creator>Streetman, Daniel S</creator><general>SAGE Publications</general><general>Whitney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>Effect of Tablet Splitting on Serum Cholesterol Concentrations</title><author>Duncan, Megan C ; Castle, Sharon S ; Streetman, Daniel S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Atorvastatin Calcium</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cross-Over Studies</topic><topic>Drug Costs</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heptanoic Acids - administration & dosage</topic><topic>Heptanoic Acids - economics</topic><topic>Heptanoic Acids - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrroles - administration & dosage</topic><topic>Pyrroles - economics</topic><topic>Pyrroles - pharmacology</topic><topic>Retrospective Studies</topic><topic>Simvastatin - administration & dosage</topic><topic>Simvastatin - economics</topic><topic>Simvastatin - pharmacology</topic><topic>Tablets</topic><topic>West Virginia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, Megan C</creatorcontrib><creatorcontrib>Castle, Sharon S</creatorcontrib><creatorcontrib>Streetman, Daniel S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, Megan C</au><au>Castle, Sharon S</au><au>Streetman, Daniel S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Tablet Splitting on Serum Cholesterol Concentrations</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>36</volume><issue>2</issue><spage>205</spage><epage>209</epage><pages>205-209</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><coden>APHRER</coden><abstract>OBJECTIVE:
To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
DESIGN:
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
SETTING:
Veterans Affairs Medical Center in Huntington, WV.
PATIENTS:
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6–8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level >400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes.
MEASUREMENT OUTCOMES:
The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
RESULTS:
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
CONCLUSIONS:
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center.</abstract><cop>Cincinnati, OH</cop><pub>SAGE Publications</pub><pmid>11847935</pmid><doi>10.1345/aph.1A233</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Annals of pharmacotherapy, 2002-02, Vol.36 (2), p.205-209 |
| issn | 1060-0280 1542-6270 |
| language | eng |
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| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Atorvastatin Calcium Biological and medical sciences Cholesterol - blood Cholesterol, LDL - blood Cross-Over Studies Drug Costs Female General and cellular metabolism. Vitamins Heptanoic Acids - administration & dosage Heptanoic Acids - economics Heptanoic Acids - pharmacology Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Pyrroles - administration & dosage Pyrroles - economics Pyrroles - pharmacology Retrospective Studies Simvastatin - administration & dosage Simvastatin - economics Simvastatin - pharmacology Tablets West Virginia |
| title | Effect of Tablet Splitting on Serum Cholesterol Concentrations |
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