Role of the Retinoblastoma Family in Gynecological Cancer

The cell cycle consists of a series of events that regulate cell life. The regulation and coordination results from a combination of several signals from different regulatory pathways which are activated in response to the presence of the right stimuli. Tumor suppressor genes represent a crucial mil...

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Bibliographic Details
Published in:Cancer biology & therapy 2003-11, Vol.2 (6), p.636-641
Main Authors: Sanseverino, Francesca, Torricelli, Michela, Petraglia, Felice, Giordano, Antonio
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Cyclin-Dependent Kinases - antagonists & inhibitors
Cyclins
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Female
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Genes, Tumor Suppressor
Humans
Landes
Models, Biological
Organogenesis
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Prognosis
Proteins
Retinoblastoma Protein - genetics
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - pathology
Vulvar Neoplasms - genetics
Vulvar Neoplasms - pathology
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Summary:The cell cycle consists of a series of events that regulate cell life. The regulation and coordination results from a combination of several signals from different regulatory pathways which are activated in response to the presence of the right stimuli. Tumor suppressor genes represent a crucial milestone in the understanding of cancer genetics. The RB gene family includes three members: Rb/p105, p107 and RB2/p130. The regulation of all three members of the retinoblastoma family of proteins is complex and unique for each single member. Each member of the RB family of growth suppressive nuclear phosphoproteins elicits G1 growth arrest upon ectopic expression in sensitive cell lines, and their phosphorylation status is regulated in a cell cycle-dependent manner. In this review, we will discuss the role of Rb family members in pathogenesis and prognosis of and therapeutic impact on gynecological cancer.
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.2.6.679