Association of Interleukin-18 Gene Promoter Polymorphisms in Type 1 Diabetes and Autoimmune Thyroid Disease

: Type 1 diabetes is a heterogeneous autoimmune disease and is often associated with other organ‐specific autoimmune diseases, including autoimmune thyroid disease (AITD). IL‐18 is a potent proinflammatory cytokine capable of inducing IFN‐γ production that is associated with the development of type...

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Published in:Annals of the New York Academy of Sciences 2003-11, Vol.1005 (1), p.436-439
Main Authors: IDE, AKANE, KAWASAKI, EIJI, ABIRU, NORIO, SUN, FUYAN, FUKUSHIMA, TETSUYA, ISHII, REIKO, TAKAHASHI, RYOKO, KUWAHARA, HIRONAGA, FUJITA, NARUHIRO, KITA, ATSUSHI, IMAIZUMI, MISA, OSHIMA, KATSUYA, USA, TOSHIRO, UOTANI, SHIGEO, EJIMA, ERI, YAMASAKI, HIRONORI, ASHIZAWA, KIYOTO, YAMAGUCHI, YOSHIHIKO, EGUCHI, KATSUMI
Format: Article
Language:English
Subjects:
Adult
Autoimmune Diseases - genetics
autoimmune thyroid disease (AITD)
Diabetes Mellitus, Type 1 - genetics
Female
Genetic Predisposition to Disease
genetics
Humans
IL-18
Interleukin-18 - blood
Interleukin-18 - genetics
Male
Middle Aged
polymorphism
Polymorphism, Genetic
Promoter Regions, Genetic
SNPs
Thyroid Diseases - genetics
type 1 diabetes
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Summary:: Type 1 diabetes is a heterogeneous autoimmune disease and is often associated with other organ‐specific autoimmune diseases, including autoimmune thyroid disease (AITD). IL‐18 is a potent proinflammatory cytokine capable of inducing IFN‐γ production that is associated with the development of type 1 diabetes and AITD. The gene for IL‐18 is located near Idd2 and has been reported to be associated with a susceptibility to type 1 diabetes. To test the putative involvement of IL‐18 gene polymorphism in predisposition to type 1 diabetes and AITD, we conducted a case‐control study in Japanese population. The SNPs at position −607 (C/A) and −137 (G/C) in the promoter region of the IL‐18 gene were analyzed by sequence‐specific PCR in 74 nondiabetic patients with AITD, 47 type 1 diabetic patients with AITD, and 114 normal controls. There was no significant increase in the genotype and allele frequencies not only in nondiabetic patients with AITD compared with normal controls, but also in type 1 diabetic patients with AITD compared with normal controls. The distribution of IL‐18 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that polymorphisms of the IL‐18 gene are not associated with a susceptibility to AITD and type 1 diabetes coexistent with AITD in Japanese population.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1288.074