Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain – but not...

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Bibliographic Details
Published in:FEBS letters 2003-12, Vol.555 (3), p.631-637
Main Authors: Hoeks, Joris, Hesselink, Matthijs K.C, van Bilsen, Marc, Schaart, Gert, van der Vusse, Ger J, Saris, Wim H.M, Schrauwen, Patrick
Format: Article
Language:English
Subjects:
Adaptation, Physiological - drug effects
Adaptation, Physiological - physiology
Animal Nutritional Physiological Phenomena
Animals
Body Weight - drug effects
Body Weight - physiology
Carrier Proteins - biosynthesis
Energy Intake - drug effects
Energy Intake - physiology
High-fat diet
Ion Channels
Lipotoxicity
Male
Medium chain triacylglycerol
Mitochondrial Proteins
Mitochondrion
Muscle, Skeletal - metabolism
Myocardium - metabolism
Peroxisome proliferator-activated receptor
Rats
Rats, Wistar
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
Thermogenesis
Transcription Factors - genetics
Transcription Factors - metabolism
Triglycerides - chemistry
Triglycerides - metabolism
Triglycerides - pharmacology
UCP3
Uncoupling Protein 3
Up-Regulation
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Summary:We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain – but not medium chain – fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esterified fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)-responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(03)01343-7