The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2003-01 (23), p.2862-2863
Main Authors: Djedovic, Natasha, Ferdani, Riccardo, Harder, Egan, Pajewska, Jolanta, Pajewski, Robert, Schlesinger, Paul H, Gokel, George W
Format: Article
Language:English
Subjects:
Anions - metabolism
Cell Membrane - metabolism
Chlorides - metabolism
Esters - chemistry
Ion Channels - chemistry
Ion Channels - metabolism
Ion Transport
Liposomes - metabolism
Molecular Structure
Peptides - chemistry
Peptides - metabolism
Phospholipids - metabolism
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Summary:Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.
ISSN:1359-7345
1364-548X
DOI:10.1039/b312209n