The continuing challenge of intra-abdominal infection

Intra-abdominal infection is common and frequently seen by the surgeon. Mortality is related to disease acuity and organ failure. This report, based on medical literature and personal experience, is a brief review of this subject, highlighting important historical milestones and recent advances in s...

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Bibliographic Details
Published in:The American journal of surgery 2003-11, Vol.186 (5), p.15-22
Main Authors: Cheadle, William G, Spain, David A
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Cavity - microbiology
Anti-Bacterial Agents - therapeutic use
Bacterial Infections - complications
Bacterial Infections - drug therapy
Bacterial Infections - surgery
Biological and medical sciences
General aspects
Human infectious diseases. Experimental studies and models
Humans
Infections
Infectious diseases
Medical sciences
Mortality
Respiratory distress syndrome
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Summary:Intra-abdominal infection is common and frequently seen by the surgeon. Mortality is related to disease acuity and organ failure. This report, based on medical literature and personal experience, is a brief review of this subject, highlighting important historical milestones and recent advances in surgical and antibiotic therapy. Peritonitis remains a clinical challenge. Aggressive resuscitation, diagnostic imaging, and surgical treatment are the mainstays of appropriate therapy. Percutaneous drainage of intra-abdominal collections has increased over time and is particularly helpful in certain postoperative patients. Adjunctive antibiotic therapy against gram-negative aerobes and anaerobes should be limited to a 7- to 10-day course, except in selected patients, such as those with inadequate source controls.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2003.10.003