Overexpression of the oncogenic kinase Pim-1 leads to genomic instability

Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a de...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (23), p.8079-8084
Main Authors: ROH, Meejeon, GARY, Bernard, CHISU SONG, SAID-AL-NAIEF, Nasser, TOUSSON, Albert, KRAFT, Andrew, ELTOUM, Isam-Eldin, ABDULKADIR, Sarki A
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Cell Cycle - physiology
Cell Line, Tumor
Chromosome Segregation
Epithelial Cells - enzymology
Epithelial Cells - pathology
Humans
Male
Medical sciences
Mitosis - genetics
Pharmacology. Drug treatments
Polyploidy
Prostate - enzymology
Prostate - physiology
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Protein-Serine-Threonine Kinases - biosynthesis
Protein-Serine-Threonine Kinases - genetics
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-pim-1
Spindle Apparatus - genetics
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
ISSN:0008-5472
1538-7445