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Overexpression of the oncogenic kinase Pim-1 leads to genomic instability
Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a de...
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| Published in: | Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (23), p.8079-8084 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| container_end_page | 8084 |
| container_issue | 23 |
| container_start_page | 8079 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 63 |
| creator | ROH, Meejeon GARY, Bernard CHISU SONG SAID-AL-NAIEF, Nasser TOUSSON, Albert KRAFT, Andrew ELTOUM, Isam-Eldin ABDULKADIR, Sarki A |
| description | Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors. |
| format | article |
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Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. 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Drug treatments ; Polyploidy ; Prostate - enzymology ; Prostate - physiology ; Prostatic Neoplasms - enzymology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Protein-Serine-Threonine Kinases - biosynthesis ; Protein-Serine-Threonine Kinases - genetics ; Proto-Oncogene Proteins - biosynthesis ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-pim-1 ; Spindle Apparatus - genetics ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8079-8084</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15363246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14678956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROH, Meejeon</creatorcontrib><creatorcontrib>GARY, Bernard</creatorcontrib><creatorcontrib>CHISU SONG</creatorcontrib><creatorcontrib>SAID-AL-NAIEF, Nasser</creatorcontrib><creatorcontrib>TOUSSON, Albert</creatorcontrib><creatorcontrib>KRAFT, Andrew</creatorcontrib><creatorcontrib>ELTOUM, Isam-Eldin</creatorcontrib><creatorcontrib>ABDULKADIR, Sarki A</creatorcontrib><title>Overexpression of the oncogenic kinase Pim-1 leads to genomic instability</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle - physiology</subject><subject>Cell Line, Tumor</subject><subject>Chromosome Segregation</subject><subject>Epithelial Cells - enzymology</subject><subject>Epithelial Cells - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitosis - genetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyploidy</subject><subject>Prostate - enzymology</subject><subject>Prostate - physiology</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Protein-Serine-Threonine Kinases - biosynthesis</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-pim-1</subject><subject>Spindle Apparatus - genetics</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0EtLw0AUBeBBFFurf0Fmo7vAPHJnJkspPgpCXeg63Elu7GiSqZlU7L83YMWlq8PlfNzFOWJzCdplNs_hmM2FEC6D3KoZO0vpbTpBCjhlM5kb6wowc7Zaf9JAX9uBUgqx57Hh44Z47Kv4Sn2o-HvoMRF_Cl0meUtYJz5GPnWxm9rQpxF9aMO4P2cnDbaJLg65YC93t8_Lh-xxfb9a3jxmGy3UmBVQi8Jrj0J5KACNqrzVBq3ypgaiuvEO0FmguvaNBUeA6IzWedNYVKAX7Prn73aIHztKY9mFVFHbYk9xl0orcytU8T-UhTKFdHaClwe48x3V5XYIHQ778nelCVwdAKYK22bAvgrpz4E2WuVGfwN29nGM</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>ROH, Meejeon</creator><creator>GARY, Bernard</creator><creator>CHISU SONG</creator><creator>SAID-AL-NAIEF, Nasser</creator><creator>TOUSSON, Albert</creator><creator>KRAFT, Andrew</creator><creator>ELTOUM, Isam-Eldin</creator><creator>ABDULKADIR, Sarki A</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Overexpression of the oncogenic kinase Pim-1 leads to genomic instability</title><author>ROH, Meejeon ; GARY, Bernard ; CHISU SONG ; SAID-AL-NAIEF, Nasser ; TOUSSON, Albert ; KRAFT, Andrew ; ELTOUM, Isam-Eldin ; ABDULKADIR, Sarki A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h302t-95d09b3ba02b595a62cb736a72b6d5eedfb85a875eddbf758e5aa86334ff7a253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle - physiology</topic><topic>Cell Line, Tumor</topic><topic>Chromosome Segregation</topic><topic>Epithelial Cells - enzymology</topic><topic>Epithelial Cells - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitosis - genetics</topic><topic>Pharmacology. 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Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>14678956</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8079-8084 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| subjects | Antineoplastic agents Biological and medical sciences Cell Cycle - physiology Cell Line, Tumor Chromosome Segregation Epithelial Cells - enzymology Epithelial Cells - pathology Humans Male Medical sciences Mitosis - genetics Pharmacology. Drug treatments Polyploidy Prostate - enzymology Prostate - physiology Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-pim-1 Spindle Apparatus - genetics Tumors |
| title | Overexpression of the oncogenic kinase Pim-1 leads to genomic instability |
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