Running endurance abnormality in mdx mice

The mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contras...

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Bibliographic Details
Published in:Muscle & nerve 2002-02, Vol.25 (2), p.207-211
Main Authors: Hara, Hajime, Nolan, Patrick M., Scott, Marion O., Bucan, Maja, Wakayama, Yoshihiro, Fischbeck, Kenneth H.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Animals, Newborn - physiology
Biological and medical sciences
Diseases of striated muscles. Neuromuscular diseases
Duchenne muscular dystrophy
dystrophin
Female
Male
mdx mouse
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred mdx - physiology
Motor Activity - physiology
Neurology
phenotype analysis
Physical Endurance - physiology
Reference Values
running wheel
Time Factors
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Summary:The mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contrast to the continuous running seen in controls. The average continuous running time differed significantly between mdx and control mice at all ages tested (5–21 weeks). This assay is noninvasive, has the advantage of unbiased automatic data collection, and should be useful for quantifying the mdx deficit in therapeutic studies. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 207–211, 2002 DOI 10.1002/mus.10021
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.10023