Immunogenicity of chi4127 phoP- Salmonella enterica serovar Typhimurium in dogs

Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly...

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Bibliographic Details
Published in:Vaccine 2002-02, Vol.20 (11-12), p.1618-1623
Main Authors: McVey, D Scott, Chengappa, M M, Mosier, Derek E, Stone, Gregory G, Oberst, Richard D, Sylte, Matt J, Gabbert, Nathan M, Kelly-Aehle, Sandra M, Curtiss, Roy
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - blood
Dogs
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - prevention & control
Gastrointestinal Diseases - veterinary
Immunity, Mucosal
Immunoglobulin G - blood
Respiratory Tract Diseases - immunology
Respiratory Tract Diseases - prevention & control
Respiratory Tract Diseases - veterinary
Salmonella Infections, Animal - immunology
Salmonella Infections, Animal - prevention & control
Salmonella typhimurium - classification
Salmonella typhimurium - immunology
Salmonella typhimurium - isolation & purification
Salmonella Vaccines - pharmacology
Serotyping
Vaccines, Attenuated - pharmacology
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Summary:Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly 40%. To date, there has been little effort to evaluate the feasibility of a vaccine for control of this disease in dogs. In the studies described here, an attenuated strain of Salmonella enterica serovar Typhimurium (Se Typhimurium), chi4127, was capable of establishing a limited infection in dogs. The chi4127-attenuated salmonellae efficiently stimulated protective immune responses in serotype homologous, direct, oral challenge experiments. Morbidity in the wild-type-challenged dogs was 8.3% in immunized dogs but 100% in the non-vaccinated controls. In (9/12) control dogs, the disease involved both gastrointestinal and respiratory tracts with high fever (>40.2 degrees C) that persisted through 5 days after challenge. Serum IgG response against S. typhimurium lipopolysaccharide (LPS) significantly increased (P
ISSN:0264-410X