It's time for chronotherapy

The EORTC Chronotherapy Group (CTG) stemmed from the International Organisation for Cancer Chronotherapy (IOCC) in 1996. The IOCC was first to initiate large scale multicentre international chronotherapy trials, for the purpose of investigating the relevance of chronomodulated or timed administratio...

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Bibliographic Details
Published in:European journal of cancer (1990) 2002-03, Vol.38, p.50-53
Main Authors: Coudert, B, Focan, C, Donato di Paola, E, Lévi, F
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Chronobiology
Chronoefficacy
Chronotherapy
Chronotherapy - methods
Chronotolerance
Circadian Rhythm
Circadian rhythms
Clinical Trials as Topic - methods
Drug Administration Schedule
Europe
Humans
International Agencies
Medical Oncology
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Summary:The EORTC Chronotherapy Group (CTG) stemmed from the International Organisation for Cancer Chronotherapy (IOCC) in 1996. The IOCC was first to initiate large scale multicentre international chronotherapy trials, for the purpose of investigating the relevance of chronomodulated or timed administration of cancer therapy based on biological rhythms. Programmable pumps for cytotoxic chronodelivery and actigraph devices to monitor circadian rhythm alterations linked to cancer were also developed. The unique expertise of the IOCC with regard to cancer chronotherapy furthered its development within the EORTC. The EORTC offers broad expertise in clinical cancer research and opportunities for scientific recognition, intergroup collaborations and translational research. Over the past 5 years, the EORTC CTG has grown from 16 to 48 centres in 12 different countries. It is currently conducting seven multicentre chronotherapy trials which test the relevance of adapting cancer treatment delivery to circadian rhythms. The group aims at developing multiple collaborations to establish a chronotherapy network involving institutions with expertise ranging from experimental chronobiology to new drug testing, disease-specific management and quality of life or survival issues.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(01)00447-6