Serum cytokine profiles in patients with adult onset Still's disease

OBJECTIVE: Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by fever, arthritis, and rash. Although the pathogenesis is not known, immunologically mediated inflammation occurs in active AOSD. To evaluate the pathogenesis and disease activity of AOSD, we measu...

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Published in:Journal of rheumatology 2003-11, Vol.30 (11), p.2422-2427
Main Authors: CHOI, Jeong-Hee, SUH, Chang-Hee, LEE, Young-Mok, SUH, Yu-Jin, LEE, Soo-Keol, KIM, Sun-Sin, NAHM, Dong-Ho, PARK, Hae-Sim
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Case-Control Studies
Cytokines - blood
Diseases of the osteoarticular system
Enzyme-Linked Immunosorbent Assay
Female
Ferritins - blood
Humans
Inflammatory joint diseases
Interferon-gamma - blood
Interleukin-18 - blood
Male
Medical sciences
Receptors, Interleukin-2 - blood
Retrospective Studies
Still's Disease, Adult-Onset - blood
Still's Disease, Adult-Onset - drug therapy
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Summary:OBJECTIVE: Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by fever, arthritis, and rash. Although the pathogenesis is not known, immunologically mediated inflammation occurs in active AOSD. To evaluate the pathogenesis and disease activity of AOSD, we measured serial serum concentrations of several cytokines in patients with active and inactive disease. METHODS: Seventeen patients diagnosed as having AOSD were enrolled. We analyzed clinical and laboratory findings retrospectively. Serial serum samples were obtained from 14 patients with active and inactive AOSD. Interleukin 18 (IL-18), soluble IL-2 receptor (sIL-2R), IL-6, interferon-g (IFN-g), and IL-8 were determined by ELISA. RESULTS: Serum levels of IL-18, IFN-g, and IL-8 were significantly higher in patients with AOSD than in healthy controls (p < 0.01), but there were no significant differences between patients with active and inactive AOSD. Serum sIL-2R levels tended to be higher in the active state than in healthy controls, but there was no statistically significant difference between the 2 groups. Serum sIL-2R levels decreased significantly with antiinflammatory therapy (p < 0.05). Serum IL-18 and sIL-2R levels correlated significantly with serum ferritin levels in the active AOSD group (p < 0.05). CONCLUSION: Overproduction of IL-18 may contribute to the pathogenic mechanism of AOSD, and serum sIL-2R levels may be used as a marker for monitoring disease activity in AOSD.
ISSN:0315-162X
1499-2752