SK channels and the varieties of slow after-hyperpolarizations in neurons

Action potentials and associated Ca2+ influx can be followed by slow after‐hyperpolarizations (sAHPs) caused by a voltage‐insensitive, Ca2+‐dependent K+ current. Slow AHPs are a widespread phenomenon in mammalian (including human) neurons and are present in both peripheral and central nervous system...

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Bibliographic Details
Published in:The European journal of neuroscience 2003-12, Vol.18 (12), p.3155-3166
Main Authors: Vogalis, Fivos, Storm, Johan F., Lancaster, Barrie
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
apamin
Ca2+-dependent K+ current
Calcium - metabolism
Calcium Signaling - physiology
Cell Membrane - physiology
Humans
Mammalia
Neurons - physiology
potassium channel
Potassium Channels - genetics
Potassium Channels - metabolism
Potassium Channels, Calcium-Activated
Protein Subunits - physiology
Small-Conductance Calcium-Activated Potassium Channels
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Summary:Action potentials and associated Ca2+ influx can be followed by slow after‐hyperpolarizations (sAHPs) caused by a voltage‐insensitive, Ca2+‐dependent K+ current. Slow AHPs are a widespread phenomenon in mammalian (including human) neurons and are present in both peripheral and central nervous systems. Although, the molecular identity of ion channels responsible for common membrane potential mechanisms has been largely determined, the nature of the channels that underlie the sAHPs in neurons, both in the brain and in the periphery, remains unresolved. This short review discusses why there is no clear molecular candidate for sAHPs.
ISSN:0953-816X
1460-9568
DOI:10.1111/j.1460-9568.2003.03040.x