Significance of serum vascular endothelial growth factor, insulin-like growth factor-I levels and nitric oxide activity in breast cancer patients

Vascular endothelial growth factor (VEGF) is used to evaluate the angiogenic activity in breast carcinoma. Nitric oxide (NO) and insulin-like growth factor-I (IGF-I) are also implicated in breast tumorigenesis, including angiogenesis. We measured serum VEGF, IGF-I and nitrate+nitrite levels in 38 pa...

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Bibliographic Details
Published in:Breast (Edinburgh) 2003-04, Vol.12 (2), p.104-110
Main Authors: Coşkun, Uǧur, Günel, Nazan, Sancak, Banu, Günel, Uǧur, Onuk, Erhan, Bayram, Orhan, Yı́lmaz, Erdal, Candan, Sakine, Ozkan, Secil
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - blood
Biopsy, Needle
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - pathology
Endothelial Growth Factors - analysis
Endothelial Growth Factors - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
IGF-I
Insulin-Like Growth Factor I - analysis
Middle Aged
Neoplasm Staging
Nitrate
Nitric Oxide - analysis
Nitric Oxide - blood
Nitrite
Probability
Prognosis
Prospective Studies
Reference Values
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Turkey
VEGF
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Summary:Vascular endothelial growth factor (VEGF) is used to evaluate the angiogenic activity in breast carcinoma. Nitric oxide (NO) and insulin-like growth factor-I (IGF-I) are also implicated in breast tumorigenesis, including angiogenesis. We measured serum VEGF, IGF-I and nitrate+nitrite levels in 38 patients with metastatic and 23 with nonmetastatic breast cancer and in 16 controls. Serum VEGF and IGF-I levels were higher in patients with metastatic disease than in those with nonmetastatic disease or in controls ( P
ISSN:0960-9776
1532-3080
DOI:10.1016/S0960-9776(02)00214-X