MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings

To assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to monitor residual tumor following non-invasive MRI-guided focused ultrasound surgery (MRIgFUS) of breast tumors. DCE-MRI data were acquired before and after the MRIgFUS treatment of small breast tumors...

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Bibliographic Details
Published in:Breast cancer research and treatment 2003-11, Vol.82 (2), p.93-101
Main Authors: GIANFELICE, David, KHIAT, Abdesslem, AMARA, Mourad, BELBLIDIA, Assia, BOULANGER, Yvan
Format: Article
Language:English
Subjects:
Aged
Algorithms
Biological and medical sciences
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer research
Cancer therapies
Contrast Media - administration & dosage
Female
Gynecology. Andrology. Obstetrics
Humans
Image Enhancement
Magnetic Resonance Imaging - methods
Mammary gland diseases
Medical sciences
Middle Aged
NMR
Nuclear magnetic resonance
Surgery
Tumors
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Summary:To assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to monitor residual tumor following non-invasive MRI-guided focused ultrasound surgery (MRIgFUS) of breast tumors. DCE-MRI data were acquired before and after the MRIgFUS treatment of small breast tumors (d < 3.5 cm) for 17 patients. The lesion was surgically resected and the presence of residual tumor was determined by histopathological analysis. The percentage of residual tumor was correlated with three DCE-MRI parameters measured at the maximally enhancing site of each tumor: increase in signal intensity (ISI), maximum difference function (MDF) and positive enhancement integral (PEI). A good correlation was found between the ISI (r = 0.897), MDF (r = 0.789) and PEI (r = 0.859) parameters and the percentage of residual viable tumor determined by histopathology. A receiver operator characteristic curve analysis yielded a cutoff value for ISI at 20% with a sensitivity of 77% and a specificity of 100%. These results suggest that parameters from DCE-MRI data could provide a reliable non-invasive method for assessing residual tumor following MRIgFUS treatment of breast tumors.
ISSN:0167-6806
1573-7217
DOI:10.1023/B:BREA.0000003956.11376.5b