Infection and Nitric Oxide

The author describes how his experience as an infectious disease fellow at Stanford University with Jack Remington from 1969 to 1971 influenced the direction of his subsequent laboratory investigation. The author reviews a series of studies that were intended to provide a mechanistic understanding o...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-02, Vol.185 (Supplement-1), p.S9-S17
Main Author: Hibbs, John B.
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Biological and medical sciences
Blood vessels and receptors
Cytokines - immunology
Cytotoxicity
Fundamental and applied biological sciences. Psychology
History, 20th Century
Infection - history
Infection - immunology
Infections
L-Arginine
Macrophage Activation
Macrophages
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Microbiology
Nitric Oxide - biosynthesis
Nitric Oxide - history
Nitrites
Nitrogen oxides
Oxides
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Somatic cells
Tumors
Vertebrates: cardiovascular system
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Summary:The author describes how his experience as an infectious disease fellow at Stanford University with Jack Remington from 1969 to 1971 influenced the direction of his subsequent laboratory investigation. The author reviews a series of studies that were intended to provide a mechanistic understanding of an in vitro cytotoxicity assay developed while he was a fellow with Jack Remington. These investigations resulted in the 1987 discovery of the synthesis of nitric oxide from l-arginine by cytokine-activated macrophages. This work provided the components (the precursor, products, and an inhibitor) of the enzymatic synthesis of nitric oxide by all three later-identified nitric oxide synthase isoforms. The significance of cytokine-induced nitric oxide synthesis during innate resistance and cell-mediated immune reactions is discussed briefly.
ISSN:0022-1899
1537-6613
DOI:10.1086/338005