Titin and nebulin content in human skeletal muscle following eccentric resistance exercise

We measured titin and nebulin content in muscle biopsies from the vastus lateralis before and 24 h after one bout of high‐intensity eccentric knee extensor resistance exercise in seven men (26 ± 3 years). Titin and nebulin content were significantly (P < 0.05) reduced after exercise by 30 and 15%...

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Bibliographic Details
Published in:Muscle & nerve 2002-02, Vol.25 (2), p.289-292
Main Authors: Trappe, Todd A., Carrithers, John A., White, Faber, Lambert, Charles P., Evans, William J., Dennis, Richard A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Connectin
contractile proteins
Fundamental and applied biological sciences. Psychology
Humans
Male
muscle damage
Muscle Proteins - metabolism
Muscle, Skeletal - metabolism
myofibril
nebulin
Protein Kinases - metabolism
proteolysis
Striated muscle. Tendons
titin
Vertebrates: osteoarticular system, musculoskeletal system
Weight Lifting - physiology
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Summary:We measured titin and nebulin content in muscle biopsies from the vastus lateralis before and 24 h after one bout of high‐intensity eccentric knee extensor resistance exercise in seven men (26 ± 3 years). Titin and nebulin content were significantly (P < 0.05) reduced after exercise by 30 and 15%, respectively. These results suggest that the structural components of the myofibrillar apparatus are degraded following high‐intensity eccentric resistance exercise in humans. Loss of these proteins may have important implications for the mechanisms regulating the adaptive response of skeletal muscle to resistance exercise. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 289–292, 2002 DOI 10.1002/mus. 10037
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.10037